Caries preventive potential of professionally deliverable fluoride-containing agents with incorporated arginine: A scoping review

IF 5.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Japanese Dental Science Review Pub Date : 2024-05-22 DOI:10.1016/j.jdsr.2024.05.002

Nouf Ali Alblooshi , Tiba Kahtan Naseer , Mohammed Nadeem Bijle

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引用次数: 0

Abstract

The scoping review objectives were to: 1) investigate the caries preventive potential of professionally deliverable fluoride (F)-containing agents with incorporated arginine (Arg); and 2) identify the future scope of research on Arg-F interventions for caries prevention. Of 150 identified records, 7 articles (6 in vitro investigations and 1 scoping review) were included for a complete review; with no clinical studies with/without appraisal. Arginine variants (L-Arg/Arg.HCl at 1% to 10% w/v.) were examined for a potential professional application aimed at caries prevention, as reported with in vitro studies. Of the included articles, four in vitro studies explored L-Arg enriched 5% NaF varnish (Duraphat®) as a promising caries preventive agent, while only one considered incorporating L-Arg in MI varnish®/nanohydroxyapatite and one investigated glass ionomer cement for primary/secondary and tertiary caries prevention. The scoping review highlighted the scope for incorporating Arg to professionally deliverable F-containing agents. No clinical data are available to make conclusive recommendations about the caries preventive potential of professionally deliverable F-containing agents with incorporated Arg. With Arg-F varnish being investigated predominantly through in vitro studies, the data so far suggest that Arg was incorporated exclusively in Duraphat®, while the potential of Arg to prevent caries in other F-containing varnishes remains unexplored.

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含有精氨酸的专业给药含氟制剂的龋齿预防潜力：范围审查

范围界定审查的目标是1）研究含有精氨酸（Arg）的专业递送型含氟（F）制剂的龋齿预防潜力；以及 2）确定 Arg-F 预防龋齿干预措施的未来研究范围。在已确定的 150 份记录中，有 7 篇文章（6 篇体外调查和 1 篇范围审查）被纳入完整审查；没有进行临床研究，也没有进行评估。根据体外研究报告，对精氨酸变体（L-Arg/Arg.HCl，1%-10% w/v.）进行了检查，以了解其在预防龋齿方面的潜在专业应用。在收录的文章中，有四项体外研究探讨了将富含 L-Arg 的 5%NaF清漆（Duraphat®）作为一种很有前景的龋病预防剂，只有一项研究考虑了将 L-Arg 加入 MI 清漆®/纳米羟基磷灰石中，还有一项研究调查了用于一级/二级和三级预防龋病的玻璃离聚体水泥。范围界定审查强调了将 Arg 加入可专业递送的含氟制剂的范围。目前还没有临床数据可以对添加了 Arg 的专业含氟牙剂的龋齿预防潜力提出结论性建议。Arg-F清漆主要通过体外研究进行调查，迄今为止的数据表明，Arg仅被纳入Duraphat®中，而Arg在其他含氟清漆中预防龋齿的潜力仍有待探索。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Japanese Dental Science Review DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

9.90

自引率

1.50%

发文量

审稿时长

32 days

期刊介绍： The Japanese Dental Science Review is published by the Japanese Association for Dental Science aiming to introduce the modern aspects of the dental basic and clinical sciences in Japan, and to share and discuss the update information with foreign researchers and dentists for further development of dentistry. In principle, papers are written and submitted on the invitation of one of the Editors, although the Editors would be glad to receive suggestions. Proposals for review articles should be sent by the authors to one of the Editors by e-mail. All submitted papers are subject to the peer- refereeing process.