Altered serum antibody levels in children with periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-06-14 eCollection Date: 2024-03-01 DOI:10.46497/ArchRheumatol.2023.9988

Umut Gazi, Ceyhun Dalkan, Burcin Sanlidag, Zeynep Cerit, Ilke Beyitler, Nerin Narin Bahceciler

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引用次数: 0

Abstract

Objectives: This study aimed to extend the literature by analyzing immunoglobulin (Ig) A, IgE, IgG, IgG2, IgG3, and IgM antibody levels in periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) patients.

Patients and methods: This study retrospectively analyzed the antibody test results of 20 pediatric patients (10 males, 10 females; mean age: 2.5±1.5 years; range, 0.5 to 5.4 years) with and without flare who were initially evaluated for a number of underlying diseases due to periodic fever/infectious symptoms but then diagnosed with PFAPA between January 2015 and December 2020. Antibody levels were determined by chemiluminescence microparticle immunoassay. The results were retrospectively compared with a group of healthy children after the PFAPA diagnosis was confirmed.

Results: The chemiluminescence microparticle immunoassay revealed 35%, 65%, 20%, 86.6%, and 55% of PFAPA cases with low serum levels of IgA, IgG, IgG2, IgG3, and IgM respectively, while 56.2% had high IgE levels. Moreover, low serum levels of at least two antibody classes or subclasses were reported in 80% of the PFAPA children. While cases with low IgG serum levels were with the highest incidence rates among the low IgG3 PFAPA patient population, both high IgE and low IgM cases were common in the rest of the patients.

Conclusion: Our results suggest an association between PFAPA and low serum antibody levels, particularly of IgG3. Future studies are needed to confirm our conclusion.

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周期性发热、口腔炎、咽炎和宫颈腺炎患儿血清抗体水平的变化。

研究目的本研究旨在通过分析周期性发热、口腔炎、咽炎和宫颈腺炎（PFAPA）患者的免疫球蛋白（Ig）A、IgE、IgG、IgG2、IgG3和IgM抗体水平来扩展文献：本研究回顾性分析了2015年1月至2020年12月期间20名患有或未患有周期性发热/感染症状的儿科患者（男10名，女10名；平均年龄：2.5±1.5岁；范围：0.5至5.4岁）的抗体检测结果。抗体水平通过化学发光微粒子免疫测定法测定。在确诊 PFAPA 后，将结果与一组健康儿童进行回顾性比较：结果：化学发光微粒子免疫测定显示，35%、65%、20%、86.6% 和 55% 的 PFAPA 病例血清中的 IgA、IgG、IgG2、IgG3 和 IgM 水平较低，而 56.2% 的病例 IgE 水平较高。此外，80% 的 PFAPA 患儿血清中至少有两种抗体或亚类水平偏低。在低 IgG3 PFAPA 患者中，IgG 血清水平低的病例发病率最高，而在其他患者中，高 IgE 和低 IgM 病例也很常见：我们的研究结果表明，PFAPA 与低血清抗体水平（尤其是 IgG3）之间存在关联。结论：我们的研究结果表明，PFAPA 与低血清抗体水平有关，尤其是 IgG3。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.