Low Concentration of Lipoprotein(a) is an Independent Predictor of Incident Type 2 Diabetes.

IF 2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Hormone and Metabolic Research Pub Date : 2024-07-01 Epub Date: 2024-05-21 DOI:10.1055/a-2316-9124

Wenhao Liu, Guanzhao Zhang, Zifan Nie, Xiangfeng Guan, Tingting Sun, Xiaodong Jin, Bo Li

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引用次数: 0

Abstract

The aim of the study was to assess the association between lipoprotein(a) [Lp(a)] concentration and incident type 2 diabetes. A meta-analysis of qualified studies on the relationship of low levels of Lp(a) concentration with incident type 2 diabetes was conducted. PubMed and Cochrane libraries were searched for randomized controlled trials containing data on events. Seven randomized trials with 227178 subjects were included in this analysis. We found an inverse association of the levels of Lp(a) concentration with risk of type 2 diabetes with approximately 37% lower relative risk in the group with the highest concentration compared with group with the lowest concentration. The current available evidence from prospective studies suggests that there is an inverse association between the levels of Lp(a) concentration and risk of type 2 diabetes, with a higher risk of type 2 diabetes at low levels of Lp(a) concentration. Therefore, we believe that the low levels of Lp(a) concentration is an independent predictor of incident type 2 diabetes.

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低脂蛋白（a）浓度是 2 型糖尿病发病的独立预测因素。

该研究旨在评估脂蛋白（a）[Lp（a）]浓度与 2 型糖尿病发病率之间的关系。研究人员对有关低水平脂蛋白（a）浓度与 2 型糖尿病发病关系的合格研究进行了荟萃分析。在 PubMed 和 Cochrane 图书馆中搜索了包含事件数据的随机对照试验。本次分析共纳入了七项随机试验，227 178 名受试者。我们发现脂蛋白（a）浓度水平与罹患 2 型糖尿病的风险呈反向关系，浓度最高组的相对风险比浓度最低组低约 37%。前瞻性研究的现有证据表明，脂蛋白（a）浓度水平与罹患 2 型糖尿病的风险呈反向关系，脂蛋白（a）浓度水平越低，罹患 2 型糖尿病的风险越高。因此，我们认为低密度脂蛋白（a）浓度是预测 2 型糖尿病发病的一个独立指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hormone and Metabolic Research 医学-内分泌学与代谢

CiteScore

3.80

自引率

0.00%

发文量

125

审稿时长

3-8 weeks

期刊介绍： Covering the fields of endocrinology and metabolism from both, a clinical and basic science perspective, this well regarded journal publishes original articles, and short communications on cutting edge topics. Speedy publication time is given high priority, ensuring that endocrinologists worldwide get timely, fast-breaking information as it happens. Hormone and Metabolic Research presents reviews, original papers, and short communications, and includes a section on Innovative Methods. With a preference for experimental over observational studies, this journal disseminates new and reliable experimental data from across the field of endocrinology and metabolism to researchers, scientists and doctors world-wide.