The Complex Roles of Redox and Antioxidant Biology in Cancer.

IF 7.8 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL
Makiko Hayashi, Keito Okazaki, Thales Papgiannakopoulos, Hozumi Motohashi
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引用次数: 0

Abstract

Redox reactions control fundamental biochemical processes, including energy production, metabolism, respiration, detoxification, and signal transduction. Cancer cells, due to their generally active metabolism for sustained proliferation, produce high levels of reactive oxygen species (ROS) compared to normal cells and are equipped with antioxidant defense systems to counteract the detrimental effects of ROS to maintain redox homeostasis. The KEAP1-NRF2 system plays a major role in sensing and regulating endogenous antioxidant defenses in both normal and cancer cells, creating a bivalent contribution of NRF2 to cancer prevention and therapy. Cancer cells hijack the NRF2-dependent antioxidant program and exploit a very unique metabolism as a trade-off for enhanced antioxidant capacity. This work provides an overview of redox metabolism in cancer cells, highlighting the role of the KEAP1-NRF2 system, selenoproteins, sulfur metabolism, heme/iron metabolism, and antioxidants. Finally, we describe therapeutic approaches that can be leveraged to target redox metabolism in cancer.

氧化还原和抗氧化生物学在癌症中的复杂作用。
氧化还原反应控制着基本的生化过程,包括能量产生、新陈代谢、呼吸、解毒和信号转导。与正常细胞相比,癌细胞因其持续增殖而普遍活跃的新陈代谢会产生高水平的活性氧(ROS),并配备有抗氧化防御系统来抵消 ROS 的有害影响,以维持氧化还原平衡。KEAP1-NRF2 系统在感知和调节正常细胞和癌细胞的内源性抗氧化防御系统方面发挥着重要作用,从而形成了 NRF2 对癌症预防和治疗的双重贡献。癌细胞劫持了依赖 NRF2 的抗氧化程序,并利用一种非常独特的新陈代谢来换取更强的抗氧化能力。这项研究概述了癌细胞中的氧化还原代谢,强调了 KEAP1-NRF2 系统、硒蛋白、硫代谢、血红素/铁代谢和抗氧化剂的作用。最后,我们介绍了针对癌症氧化还原代谢的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cold Spring Harbor perspectives in medicine
Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
14.30
自引率
1.90%
发文量
44
审稿时长
4-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.
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