Lanthanide-dye hybrid luminophores for advanced NIR-II bioimaging

IF 5.3 2区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Applied Nano Materials Pub Date : 2024-05-21 DOI:10.1016/j.cbpa.2024.102469

Mei Mei, Bin Wu, Shangfeng Wang, Fan Zhang

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Abstract

In vivo luminescence imaging in the second near-infrared window (NIR-II, 1000–2000 nm) is a potent technique for observing deep-tissue life activities, leveraging reduced light scattering, minimized autofluorescence, and moderate absorption attenuation to substantially enhance image contrast. Pushing the frontiers of NIR-II luminescence imaging forward, moving from static to dynamic event visualization, monochromatic to multicolor images, and fundamental research to clinical applications, necessitates the development of novel luminophores featuring bright emission, extendable wavelength, and optimal biocompatibility. Recently, lanthanide-dye hybrid luminophores (LDHLs) are gaining increasing attention for their wavelength extensibility, molecular size, narrowband emission, mega stokes shift, long lifetime, and high photostability. In this review, we will summarize the recent advances of NIR-II LDHLs and their applications in imaging and analysis of living mammals, and discuss future challenges in designing new LDHLs for deep-tissue imaging.

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用于先进近红外-II 生物成像的镧系元素-染料混合发光体

第二近红外窗口（NIR-II，1000-2000 纳米）的活体发光成像是观察深部组织生命活动的有效技术，它利用减少光散射、最小化自发荧光和适度吸收衰减来大幅提高图像对比度。要推动近红外-II 发光成像技术的发展，实现从静态到动态事件可视化、从单色到多色图像、从基础研究到临床应用的转变，就必须开发出具有明亮发射、可扩展波长和最佳生物相容性的新型发光体。最近，镧系元素-染料杂化发光体（LDHLs）因其波长可延长、分子大小、窄带发射、巨型斯托克斯偏移、长寿命和高光稳定性而日益受到关注。在这篇综述中，我们将总结近红外-II LDHL 的最新进展及其在活体哺乳动物成像和分析中的应用，并讨论设计用于深部组织成像的新型 LDHL 所面临的未来挑战。

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来源期刊

ACS Applied Nano Materials Multiple-

CiteScore

8.30

自引率

3.40%

发文量

1601

期刊介绍： ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.