Modelling spatio-temporal interactions between second messengers Ca 2 + and cAMP in a pancreatic β -cell.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
ACS Applied Bio Materials Pub Date : 2024-08-01 Epub Date: 2024-05-21 DOI:10.1007/s10863-024-10021-2
Vaishali, Neeru Adlakha
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引用次数: 0

Abstract

Calcium serves as a widespread second messenger in almost every human and animal cell. The regulation of various cellular processes, such as transcriptional control and the kinetics of membrane channels, is significantly influenced by intracellular calcium ions (Ca 2 + ), and linkages between Ca 2 + and other second messengers should activate signaling networks. The passage of ions across the cell membrane regulates Ca 2 + levels in pancreatic β -cells and requires the coordinated interaction of various ion transport mechanisms and organelles. The signaling of Ca 2 + in β -cells and its interactions with the intracellular dynamics of cyclic adenosine monophosphate (cAMP) is poorly understood. Therefore, the current investigation proposes a mathematical model to illustrate the spatiotemporal dynamical interaction between Ca 2 + and cAMP. In order to construct a one-dimensional mathematical model, the fundamental initial and boundary conditions derived from the physiological characteristics of the β -cell are incorporated. The numerical results were obtained by MATLAB simulations using the finite element method and the Crank-Nicolson method. The current study aims to offer an update on regulation between Ca 2 + and cAMP signaling circuits, with a focus on interactions that occur in localized areas of the β -cell. The model gives the individual effect of each parameter on the regulation of Ca 2 + and cAMP profiles in a β -cell. Evidently, impairments in the regulation of messenger pathways contribute to the pathological conditions, as demonstrated by the results obtained.

Abstract Image

胰腺β细胞中第二信使Ca 2 +和cAMP时空相互作用建模
钙是几乎所有人类和动物细胞中广泛存在的第二信使。细胞内钙离子(Ca 2 +)对转录控制和膜通道动力学等各种细胞过程的调控有很大影响,而 Ca 2 + 与其他第二信使之间的联系应能激活信号网络。离子通过细胞膜调节胰岛β细胞内的 Ca 2 + 水平,需要各种离子转运机制和细胞器的协调互动。人们对 Ca 2 + 在β细胞中的信号传导及其与细胞内环磷酸腺苷(cAMP)动态的相互作用知之甚少。因此,本研究提出了一个数学模型来说明 Ca 2 + 和 cAMP 之间的时空动态相互作用。为了构建一维数学模型,该模型结合了从β细胞生理特征中得出的基本初始条件和边界条件。利用有限元法和 Crank-Nicolson 法,通过 MATLAB 仿真获得了数值结果。目前的研究旨在提供 Ca 2 + 和 cAMP 信号回路之间调控的最新信息,重点关注发生在 β - 细胞局部区域的相互作用。该模型给出了每个参数对 β 细胞中 Ca 2 + 和 cAMP 曲线调节的单独影响。结果表明,信使通路的调节障碍是导致病理状况的原因之一。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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