Stereotactic Radiotherapy for Penile Metastasis: Case Report and Systematic Literature Review.

IF 2 4区 医学 Q3 ONCOLOGY
Oncology Research and Treatment Pub Date : 2024-01-01 Epub Date: 2024-05-18 DOI:10.1159/000539275
Antonio Piras, Andrea D'Aviero, Antonella Sanfratello, Luca Boldrini, Gianfranco Pernice, Massimiliano Spada, Gianluca Gaudio, Mirko Pinelli, Giuseppe Salamone, Vittorio Gebbia, Nino Dispensa, Gabriele Tulone, Riccardo Laudicella, Albert Comelli, Domenico Di Raimondo, Antonino Tuttolomondo, Tommaso Angileri, Antonino Daidone
{"title":"Stereotactic Radiotherapy for Penile Metastasis: Case Report and Systematic Literature Review.","authors":"Antonio Piras, Andrea D'Aviero, Antonella Sanfratello, Luca Boldrini, Gianfranco Pernice, Massimiliano Spada, Gianluca Gaudio, Mirko Pinelli, Giuseppe Salamone, Vittorio Gebbia, Nino Dispensa, Gabriele Tulone, Riccardo Laudicella, Albert Comelli, Domenico Di Raimondo, Antonino Tuttolomondo, Tommaso Angileri, Antonino Daidone","doi":"10.1159/000539275","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Penile metastases (PMs) are a rare clinical presentation mainly related to advanced stages of disease. Considering the low incidence, an optimal treatment approach has not yet been defined; surgery, chemotherapy, and radiotherapy (RT) are different options used in the vast majority with palliative intent. The advances in modern RT can represent an innovative tool in PM management and a curative option. This paper aimed to report the case of a PM patient treated with stereotactic body radiotherapy (SBRT) and perform a systematic literature review of current evidence on the RT approach to PM.</p><p><strong>Case presentation: </strong>We reported the case of an 80-year-old patient with PM from primary bladder cancer. Following the surgical approach for the primary tumor, evidence of PM was shown, and the patient was admitted to SBRT treatment on PM after an adjuvant RT course on the pelvis. A 25 Gy in 5-fraction SBRT treatment was performed, and a complete clinical response was shown at the first follow-up. A PubMed/MEDLINE and Embase systematic review was carried out. The search strategy terms were [(\"penile metastasis\"/exp OR \"penile metastasis\" OR (penile AND (\"metastasis\"/exp OR metastasis))) AND (\"radiotherapy\"/exp OR radiotherapy)] and only original articles up to October 24, 2023 were considered.</p><p><strong>Conclusion: </strong>A total of 174 studies were obtained using the previously mentioned search strategy, and the analysis was performed on 15 papers obtained following the complete selection process. All reported evidence was focused on the palliative approach of PM, showing good results in terms of symptom control. The potential role of modern RT in the management of PM has yet to be defined. The reported case showed the feasibility and the clinical impact of SBRT in PM treatment.</p>","PeriodicalId":19543,"journal":{"name":"Oncology Research and Treatment","volume":" ","pages":"565-572"},"PeriodicalIF":2.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oncology Research and Treatment","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000539275","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/5/18 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Introduction: Penile metastases (PMs) are a rare clinical presentation mainly related to advanced stages of disease. Considering the low incidence, an optimal treatment approach has not yet been defined; surgery, chemotherapy, and radiotherapy (RT) are different options used in the vast majority with palliative intent. The advances in modern RT can represent an innovative tool in PM management and a curative option. This paper aimed to report the case of a PM patient treated with stereotactic body radiotherapy (SBRT) and perform a systematic literature review of current evidence on the RT approach to PM.

Case presentation: We reported the case of an 80-year-old patient with PM from primary bladder cancer. Following the surgical approach for the primary tumor, evidence of PM was shown, and the patient was admitted to SBRT treatment on PM after an adjuvant RT course on the pelvis. A 25 Gy in 5-fraction SBRT treatment was performed, and a complete clinical response was shown at the first follow-up. A PubMed/MEDLINE and Embase systematic review was carried out. The search strategy terms were [("penile metastasis"/exp OR "penile metastasis" OR (penile AND ("metastasis"/exp OR metastasis))) AND ("radiotherapy"/exp OR radiotherapy)] and only original articles up to October 24, 2023 were considered.

Conclusion: A total of 174 studies were obtained using the previously mentioned search strategy, and the analysis was performed on 15 papers obtained following the complete selection process. All reported evidence was focused on the palliative approach of PM, showing good results in terms of symptom control. The potential role of modern RT in the management of PM has yet to be defined. The reported case showed the feasibility and the clinical impact of SBRT in PM treatment.

阴茎转移的立体定向放射治疗:病例报告和系统文献综述。
导言:阴茎转移(PM)是一种罕见的临床表现,主要与疾病晚期有关。考虑到发病率较低,最佳治疗方法尚未确定;手术、化疗和放疗是绝大多数患者出于姑息目的而采用的不同方案。现代 RT 技术的进步是治疗肺癌的创新工具和治愈选择。本文旨在报告一例采用立体定向体部放射治疗(SBRT)的肺癌患者的病例,并对目前采用 RT 治疗肺癌的证据进行系统的文献综述。病例报告 我们报告了一例80岁的原发性膀胱癌患者。在对原发肿瘤进行手术治疗后,显示出了 PM 的证据,患者在盆腔辅助 RT 疗程后接受了 PM 的 SBRT 治疗。患者接受了 5 次分次 25 Gy 的 SBRT 治疗,在首次随访时出现了完全临床反应。方法 对 Pubmed/MEDLINE 和 Embase 进行了系统性回顾。检索关键词为[('阴茎转移'/exp 或 '阴茎转移' 或(阴茎和('转移'/exp 或转移)))和('放射治疗'/exp 或放射治疗))],并只考虑截至 2023 年 10 月 24 日的原创文章。结果 采用前述检索策略共获得 174 项研究,并对经过完整筛选过程获得的 15 篇论文进行了分析。所有报告的证据都集中在 PM 的姑息治疗方法上,显示出在症状控制方面的良好效果。讨论 现代 RT 在治疗 PM 中的潜在作用尚待确定。所报道的病例显示了SBRT在 PM 治疗中的可行性和临床效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.20
自引率
0.00%
发文量
84
期刊介绍: With the first issue in 2014, the journal ''Onkologie'' has changed its title to ''Oncology Research and Treatment''. By this change, publisher and editor set the scene for the further development of this interdisciplinary journal. The English title makes it clear that the articles are published in English – a logical step for the journal, which is listed in all relevant international databases. For excellent manuscripts, a ''Fast Track'' was introduced: The review is carried out within 2 weeks; after acceptance the papers are published online within 14 days and immediately released as ''Editor’s Choice'' to provide the authors with maximum visibility of their results. Interesting case reports are published in the section ''Novel Insights from Clinical Practice'' which clearly highlights the scientific advances which the report presents.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信