The application of CRISPR genome editing technologies in the pathogenesis studies, diagnosis, prevention and treatment of infectious diseases.

Q3 Medicine

遗传 Pub Date : 2023-11-20 DOI:10.16288/j.yczz.23-206

Zhen-Rong Yang, Gang-Qiao Zhou

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引用次数: 0

Abstract

The CRISPR genome editing technology shows great application prospects in gene manipulation and infectious disease research, and is of great value for effective control and cure of infectious diseases. It has been utilized to generate specific disease models in cells, organoids and animals, which provide great convenience for research into the molecular mechanisms associated with infectious diseases. CRISPR screening technology enables high-throughput identification of risk factors. New molecular diagnostic tools based on CRISPR offer a more sensitive and faster method for detecting pathogens. The use of CRISPR tools to introduce resistance genes or to specifically destroy risk genes and virus genomes is intended to help prevent or treat infectious diseases. This review discusses the application of CRISPR genome editing technologies in the construction of disease models, screening of risk factors, pathogen diagnosis, and prevention and treatment of infectious diseases, thereby providing a reference for follow-up research in pathogenesis, diagnosis, prevention and treatment of infectious diseases.

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将 CRISPR 基因组编辑技术应用于传染病的发病机制研究、诊断、预防和治疗。

CRISPR 基因组编辑技术在基因操作和传染病研究方面具有广阔的应用前景，对有效控制和治愈传染病具有重要价值。它已被用于在细胞、器官组织和动物中生成特定的疾病模型，为研究与传染病相关的分子机制提供了极大的便利。CRISPR 筛选技术能够高通量识别风险因素。基于 CRISPR 的新型分子诊断工具为检测病原体提供了更灵敏、更快速的方法。使用 CRISPR 工具引入抗性基因或特异性破坏风险基因和病毒基因组，旨在帮助预防或治疗传染病。本综述探讨了CRISPR基因组编辑技术在疾病模型构建、风险因素筛查、病原体诊断、传染病预防和治疗等方面的应用，从而为传染病的发病机制、诊断、预防和治疗等后续研究提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

遗传 Medicine-Medicine (all)

CiteScore

2.50

自引率

0.00%

发文量

6699

期刊介绍： Hereditas is a national academic journal sponsored by the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences and the Chinese Society of Genetics and published by Science Press. It is a Chinese core journal and a Chinese high-quality scientific journal. The journal mainly publishes innovative research papers in the fields of genetics, genomics, cell biology, developmental biology, biological evolution, genetic engineering and biotechnology; new technologies and new methods; monographs and reviews on hot issues in the discipline; academic debates and discussions; experience in genetics teaching; introductions to famous geneticists at home and abroad; genetic counseling; information on academic conferences at home and abroad, etc. Main columns: review, frontier focus, research report, technology and method, resources and platform, experimental operation guide, genetic resources, genetics teaching, scientific news, etc.