Histopathological findings of anterior lens capsule in pediatric cataract.

IF 2.1 4区 医学 Q2 OPHTHALMOLOGY
Indian Journal of Ophthalmology Pub Date : 2024-12-01 Epub Date: 2024-05-20 DOI:10.4103/IJO.IJO_2957_23
Ferhad Özer, İrem İnanç, Pınar B Kızıltunç, Hüban Atilla, Belgin Can
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Abstract

Purpose: To investigate the histopathological findings of the anterior lens capsule in pediatric patients who had surgery for cataracts.

Methods: This study is a prospective interventional study. Anterior capsule tissue samples that were obtained by the anterior capsulotomy method during phacoemulsification surgery were fixed and examined under a transmission electron microscope.

Results: Twenty-two eyes of 19 patients who were diagnosed with congenital and juvenile cataracts were included in this study. Five patients had associated systemic diseases, including hydrocephalus, cerebral palsy, prematurity, juvenile myelomonocytic leukemia, and Down's syndrome. Electron microscopic evaluation demonstrated single-layered epithelium under the capsule, degenerated organelles with round-oval and prismatic-oval nuclei, and degenerated mitochondria and heterochromatin-rich nuclei. In the case with cerebral palsy, collagen fibrils of the connective tissue and fibroblast-like cells were observed replacing the epithelium that should be underneath the capsule in both eyes, and there was a disorganized distribution of collagen fibrils and vacuole structures in the cytoplasm of fibroblast-like cells.

Conclusion: Similar histopathological findings were found in pediatric cataracts with or without systemic disease except in one cerebral palsy case. The absence of lens epithelium may have been a result of degeneration in this patient, and this can be attributed to the presence of systemic inflammation and gliosis in cerebral palsy. The absence of lens epithelium can play a role in the development of dense subcapsular fibrosis and cataract formation.

小儿白内障患者晶状体前囊的组织病理学发现。
目的:研究接受白内障手术的儿童患者晶状体前囊的组织病理学结果:本研究是一项前瞻性干预研究。方法:本研究是一项前瞻性干预研究,研究人员在进行超声乳化手术时通过前囊切开法获得前囊组织样本,将其固定并在透射电子显微镜下进行检查:本研究共纳入了19名确诊为先天性白内障和青少年白内障患者的22只眼睛。五名患者伴有全身性疾病,包括脑积水、脑瘫、早产、幼年骨髓单核细胞白血病和唐氏综合征。电子显微镜评估显示,囊下为单层上皮,细胞器退化,核呈圆形椭圆和棱形椭圆,线粒体退化,核内富含异染色质。在脑瘫病例中,观察到结缔组织的胶原纤维和成纤维样细胞取代了双眼囊下的上皮,胶原纤维分布紊乱,成纤维样细胞的细胞质中有空泡结构:除一例脑瘫病例外,有或无全身性疾病的小儿白内障均有类似的组织病理学发现。该患者的晶状体上皮缺失可能是退化的结果,这可归因于脑瘫患者存在全身炎症和胶质细胞病变。晶状体上皮的缺失可能会导致致密的囊下纤维化和白内障的形成。
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来源期刊
CiteScore
3.80
自引率
19.40%
发文量
1963
审稿时长
38 weeks
期刊介绍: Indian Journal of Ophthalmology covers clinical, experimental, basic science research and translational research studies related to medical, ethical and social issues in field of ophthalmology and vision science. Articles with clinical interest and implications will be given preference.
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