Exploring the Impact of Iron Deficiency Anaemia on Glycated Haemoglobin A1c Levels in Pregnant and Non-Pregnant Women: A Systematic Review

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-05-01 DOI:10.2147/IJWH.S462163

Amani Alqarni, Amal A Alghamdi, Hussain J Aljubran, O. Bamalan, A. Abuzaid, Mohammed A AlYahya, A. Alawami, Mohammed Al Shubbar, Ghada Al Yousif

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引用次数: 0

Abstract

Abstract Haemoglobin A1C (HbA1c) is fundamental in monitoring glycaemic control during pregnancy. However, several conditions could affect this test’s accuracy, including iron deficiency anaemia (IDA). Hence, this systematic review delves into the underexplored connection between IDA, iron replacement therapy (IRT), and haemoglobin A1C (HbA1c) during pregnancy. An electronic search of the Cochrane, MEDLINE, and Embase databases was conducted by six authors. From a comprehensive search strategy, 968 records were obtained. After applying the inclusion and exclusion criteria, seven studies were included, comprising 365 women selected for analysis. Six studies indicated a positive correlation between IDA and HbA1c levels, while one found no correlation. The average HbA1c level of the included studies in pregnant women was 5.64%. In comparison, it was found that non-pregnant women had lower HbA1c levels. Among the included studies, the mean HbA1c levels decreased from 5.1% to 4.89% after treating pregnant women with IRT. The review emphasises the complexity of interpreting HbA1c levels in pregnant women with IDA, highlighting the influence of pregnancy-induced physiological changes. In addition, this suggests that HbA1c should not be the sole criterion for diabetes management in pregnant women with IDA. Future research should focus on alternative glycaemic monitoring methods unaffected by IDA.

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探索缺铁性贫血对孕妇和非孕妇糖化血红蛋白 A1c 水平的影响：系统回顾

摘要血红蛋白 A1C（HbA1c）是监测孕期血糖控制情况的基础。然而，包括缺铁性贫血（IDA）在内的一些情况可能会影响该检测的准确性。因此，本系统综述深入探讨了孕期缺铁性贫血、铁替代疗法（IRT）和血红蛋白 A1C（HbA1c）之间尚未被充分探索的联系。六位作者对 Cochrane、MEDLINE 和 Embase 数据库进行了电子检索。通过全面的搜索策略，共获得了 968 条记录。在应用纳入和排除标准后，共纳入了 7 项研究，对其中的 365 名妇女进行了分析。六项研究表明 IDA 与 HbA1c 水平呈正相关，一项研究则发现两者之间没有相关性。纳入研究的孕妇平均 HbA1c 水平为 5.64%。相比之下，非孕妇的 HbA1c 水平较低。在纳入的研究中，孕妇接受 IRT 治疗后，HbA1c 平均水平从 5.1% 降至 4.89%。该综述强调了解释患有 IDA 的孕妇 HbA1c 水平的复杂性，突出了妊娠引起的生理变化的影响。此外，这还表明，HbA1c 不应是 IDA 孕妇糖尿病管理的唯一标准。未来的研究应侧重于不受 IDA 影响的其他血糖监测方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464