Emerging roles for stromal cells in bone metastasis

IF 3.4 2区医学 Q2 Medicine

Journal of Bone Oncology Pub Date : 2024-05-17 DOI:10.1016/j.jbo.2024.100610

Karl J. Nyman , Jeremy S. Frieling , Conor C. Lynch

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Abstract

The skeleton is a common site of cancer metastasis and malignancy with the resultant lesions often being incurable. Interactions between metastatic cancer cells and the bone microenvironment are critical for cancer cell survival, outgrowth, and progression. Mesenchymal Stem Cells (MSCs) are an essential stromal cell type in bone that are appreciated for their impacts on cancer-induced bone disease, however, newer evidence suggests that MSCs possess extensive roles in cancer-bone crosstalk, including cancer cell dormancy, metabolic demands, and immune-oncology. Emerging evidence has also identified the importance of MSC tissue source and the influence of ageing when studying MSC biology. Combining these considerations together with developing technologies such as spatial transcriptomics will contribute to defining the molecular mechanisms underlying complex stroma-cancer interactions in bone and assist with identification of therapeutically tractable targets.

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基质细胞在骨转移中的新作用

骨骼是癌症转移和恶性肿瘤的常见部位，所导致的病变往往无法治愈。转移癌细胞与骨骼微环境之间的相互作用对癌细胞的存活、生长和恶化至关重要。间充质干细胞（MSCs）是骨中一种重要的基质细胞类型，因其对癌症诱发的骨病的影响而备受关注，然而，最新的证据表明，间充质干细胞在癌症与骨的相互作用中具有广泛的作用，包括癌细胞休眠、代谢需求和免疫肿瘤学。在研究间充质干细胞生物学时，新证据还发现了间充质干细胞组织来源的重要性以及老化的影响。将这些因素与空间转录组学等发展中的技术相结合，将有助于确定骨中复杂的基质与癌症相互作用的分子机制，并帮助确定可治疗的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Bone Oncology ONCOLOGY-

CiteScore

7.20

自引率

2.90%

发文量

审稿时长

34 days

期刊介绍： The Journal of Bone Oncology is a peer-reviewed international journal aimed at presenting basic, translational and clinical high-quality research related to bone and cancer. As the first journal dedicated to cancer induced bone diseases, JBO welcomes original research articles, review articles, editorials and opinion pieces. Case reports will only be considered in exceptional circumstances and only when accompanied by a comprehensive review of the subject. The areas covered by the journal include: Bone metastases (pathophysiology, epidemiology, diagnostics, clinical features, prevention, treatment) Preclinical models of metastasis Bone microenvironment in cancer (stem cell, bone cell and cancer interactions) Bone targeted therapy (pharmacology, therapeutic targets, drug development, clinical trials, side-effects, outcome research, health economics) Cancer treatment induced bone loss (epidemiology, pathophysiology, prevention and management) Bone imaging (clinical and animal, skeletal interventional radiology) Bone biomarkers (clinical and translational applications) Radiotherapy and radio-isotopes Skeletal complications Bone pain (mechanisms and management) Orthopaedic cancer surgery Primary bone tumours Clinical guidelines Multidisciplinary care Keywords: bisphosphonate, bone, breast cancer, cancer, CTIBL, denosumab, metastasis, myeloma, osteoblast, osteoclast, osteooncology, osteo-oncology, prostate cancer, skeleton, tumour.

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