Brazil nut–enriched diet modulates bone mineral density and body composition in an experimental model of chronic kidney disease

IF 3.2 3区医学 Q2 NUTRITION & DIETETICS

Nutrition Pub Date : 2024-05-03 DOI:10.1016/j.nut.2024.112482

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引用次数: 0

Abstract

Objective

This study investigates the effects of a Brazil nut-enriched diet on body composition and bone parameters in CKD animal model.

Methods

Male Wistar rats were assigned to the following groups: Sham (n=8), Nx (n=6), nephrectomized rats, and NxBN (n=6), nephrectomized rats and an enricheddiet with 5% Brazil nut. Body composition parameters were obtained by dual-energy X- ray absorptiometry (DXA). Bioclin kits determined plasmatic calcium. The femurs werecollected to determine absolute mass and length, bone mineral density, and biomechanical tests.

Results

The NxBN group exhibited a higher total body bone mineral density (BMD) value than the Nx group (0.177±0.004g/cm²vs 0,169±0.003g/cm²; p=0.0397). No significant differences were observed regarding absolute mass, length, BMD, and biomechanical parameters in the femurs of the groups. Moreover, no significant differences were found in plasmatic calcium levels among the groups.

Conclusions

Brazil-nut enriched diet modulated BMD in CKD experimental model, and further studies are demanded to understand the pathways involved in this finding.

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富含巴西坚果的饮食可调节慢性肾脏病实验模型的骨矿物质密度和身体组成

方法将雄性 Wistar 大鼠分为以下几组：Sham 组（n=8）、Nx 组（n=6）（肾切除大鼠）和 NxBN 组（n=6）（肾切除大鼠）：方法将雄性 Wistar 大鼠分为以下几组：Sham 组（n=8）、Nx 组（n=6）（肾脏切除大鼠）和 NxBN 组（n=6）（肾脏切除大鼠和含 5%巴西坚果的丰富饮食）。身体成分参数通过双能 X 射线吸收测定法（DXA）获得。Bioclin 试剂盒测定血浆钙。结果 NxBN 组的全身骨质密度 (BMD) 值高于 Nx 组（0.177±0.004g/cm2vs 0,169±0.003g/cm2; p=0.0397）。各组股骨的绝对质量、长度、BMD 和生物力学参数均无明显差异。结论巴西坚果膳食可调节 CKD 实验模型的 BMD，需要进一步研究以了解这一发现所涉及的途径。

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来源期刊

Nutrition 医学-营养学

CiteScore

7.80

自引率

2.30%

发文量

300

审稿时长

60 days

期刊介绍： Nutrition has an open access mirror journal Nutrition: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Founded by Michael M. Meguid in the early 1980''s, Nutrition presents advances in nutrition research and science, informs its readers on new and advancing technologies and data in clinical nutrition practice, encourages the application of outcomes research and meta-analyses to problems in patient-related nutrition; and seeks to help clarify and set the research, policy and practice agenda for nutrition science to enhance human well-being in the years ahead.