Liver Histopathology in Pediatric Patients with Choledochal Cyst

Q3 Medicine

Journal of Indian Association of Pediatric Surgeons Pub Date : 2024-05-01 DOI:10.4103/jiaps.jiaps_195_23

Kumar Mayank, S. Choudhury, Smita Singh, Y. K. Sarin

{"title":"Liver Histopathology in Pediatric Patients with Choledochal Cyst","authors":"Kumar Mayank, S. Choudhury, Smita Singh, Y. K. Sarin","doi":"10.4103/jiaps.jiaps_195_23","DOIUrl":null,"url":null,"abstract":"ABSTRACT\n \n \n \n The aim is to study the various histopathological changes in the liver in pediatric patients with choledochal cyst (CC) and correlate with the presentation and type of cyst.\n \n \n \n In a prospective observational study including all pediatric patients who underwent CC excision, histopathological changes of the liver in the form of cholestasis (CHS), portal inflammation (PI), bile duct proliferation (BDP), and fibrosis were studied and graded using a scoring system. They were analyzed in relation to age, sex, symptoms, and type of the cyst.\n \n \n \n All 30 patients of CC showed various degrees of histopathological changes in the liver in the form of CHS, PI, BDP, and liver fibrosis. Patients <1 years had 9/13 (69.2%) cystic variety and those >1 years had 17/17 (100%) fusiform variety of CC (P < 0.001). Patients <1 years frequently presented with jaundice and hepatomegaly and those >1 years presented with pain abdomen (P < 0.002). Higher grades of liver fibrosis and BDP were seen in the cystic variety compared to the fusiform variety (P < 0.001). However, no significant association was found with CHS and PI (P > 1.23).\n \n \n \n Histopathological changes in the liver of varying grades are seen in all patients of CC. Patients of CC <1 year presented frequently with jaundice, had the cystic type, and had a higher degree of liver damage on histopathology.\n","PeriodicalId":16069,"journal":{"name":"Journal of Indian Association of Pediatric Surgeons","volume":"8 10","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Indian Association of Pediatric Surgeons","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jiaps.jiaps_195_23","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

ABSTRACT The aim is to study the various histopathological changes in the liver in pediatric patients with choledochal cyst (CC) and correlate with the presentation and type of cyst. In a prospective observational study including all pediatric patients who underwent CC excision, histopathological changes of the liver in the form of cholestasis (CHS), portal inflammation (PI), bile duct proliferation (BDP), and fibrosis were studied and graded using a scoring system. They were analyzed in relation to age, sex, symptoms, and type of the cyst. All 30 patients of CC showed various degrees of histopathological changes in the liver in the form of CHS, PI, BDP, and liver fibrosis. Patients <1 years had 9/13 (69.2%) cystic variety and those >1 years had 17/17 (100%) fusiform variety of CC (P < 0.001). Patients <1 years frequently presented with jaundice and hepatomegaly and those >1 years presented with pain abdomen (P < 0.002). Higher grades of liver fibrosis and BDP were seen in the cystic variety compared to the fusiform variety (P < 0.001). However, no significant association was found with CHS and PI (P > 1.23). Histopathological changes in the liver of varying grades are seen in all patients of CC. Patients of CC <1 year presented frequently with jaundice, had the cystic type, and had a higher degree of liver damage on histopathology.

查看原文本刊更多论文

胆总管囊肿儿科患者的肝组织病理学研究

摘要目的研究胆总管囊肿（CC）儿科患者肝脏的各种组织病理学变化，并将其与囊肿的表现和类型相关联。在一项前瞻性观察研究中，包括所有接受胆总管囊肿切除术的儿科患者，研究了肝脏的组织病理学变化，包括胆汁淤积（CHS）、门脉炎症（PI）、胆管增生（BDP）和纤维化，并使用评分系统进行了分级。分析结果与年龄、性别、症状和囊肿类型有关。所有30名CC患者的肝脏都出现了不同程度的组织病理学改变，表现为CHS、PI、BDP和肝纤维化。1岁患者中有17/17（100%）例为纺锤形CC（P<0.001）。1年期患者出现腹痛（P < 0.002）。与纺锤形CC相比，囊性CC的肝纤维化和BDP程度更高（P < 0.001）。然而，CHS和PI之间并无明显关联（P > 1.23）。所有CC患者的肝脏都有不同程度的组织病理学改变。病程小于1年的CC患者常伴有黄疸，属于囊肿型，组织病理学上的肝损伤程度较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Journal of Indian Association of Pediatric Surgeons Medicine-Pediatrics, Perinatology and Child Health

CiteScore

0.80

自引率

0.00%

发文量

148

审稿时长

30 weeks

期刊介绍： Journal of Indian Association of Pediatric Surgeons is the official organ of Indian Association of Pediatric Surgeons. The journal started its journey in October 1995 under the Editor-in-Chief Prof. Subir K Chatterjee. An advisory board was formed with well-versed internationally reputed senior members of our society like Late Prof. R K Gandhi, Prof. I C Pathak, Prof. P Upadhyay, Prof. T Dorairajan and many more. since then the journal is published quarterly uninterrupted. The journal publishes original articles, case reports, review articles and technical innovations. Special issues on different subjects are published every year. There have been several contributions from overseas experts.