Assessing the potential impact of livestock immunisation and acaricide use on controlling the spread of East Coast fever

IF 2 Q3 INFECTIOUS DISEASES

Parasite Epidemiology and Control Pub Date : 2024-05-01 DOI:10.1016/j.parepi.2024.e00357

Mirirai Chinyoka , Gift Muchatibaya , Prosper Jambwa , Mhosisi Masocha , Steady Mushayabasa

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引用次数: 0

Abstract

Immunisation of livestock with high-quality vaccines and the use of acaricides are highly ranked tick control strategies worldwide. However, the effects of coupling livestock immunisation and acaricide control on mitigating the spread of East Coast Fever (ECF) is not well understood. Effective strategies to curb the disease require an understanding of the influence of control strategies on ECF dynamics. This paper presents a new mathematical model for ECF in ticks and livestock to analyze the effect of livestock immunisation and acaricide control on preventing ECF spread. Our research is focused on examining how vaccine efficacy, inoculation rate, and acaricide efficacy affect disease progression. Our finding is that acaricide control alone may not be sufficient to stop the spread of ECF, even if it has an 80% effectiveness all the time. However, by pairing acaricide control with livestock vaccination, disease transmission is significantly reduced and elimination is possible under certain circumstances. Overall, results show that it is crucial to understand the influence of combining control strategies to mitigate the spread of this devastating livestock disease and enhance decision making among policymakers and livestock keepers.

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评估牲畜免疫接种和杀螨剂的使用对控制东海岸热传播的潜在影响

用优质疫苗对牲畜进行免疫接种和使用杀螨剂是全球范围内排名靠前的蜱虫控制策略。然而，将牲畜免疫和杀螨剂控制结合起来对减轻东海岸热（ECF）传播的影响还不甚了解。要采取有效策略遏制该疾病，就必须了解控制策略对东岸热动态的影响。本文提出了一种新的蜱虫和家畜ECF数学模型，以分析家畜免疫和杀螨剂控制对预防ECF传播的影响。我们的研究重点是探讨疫苗效力、接种率和杀螨剂效力如何影响疾病的发展。我们的研究结果表明，即使杀螨剂的杀螨效果始终保持在 80%，单靠杀螨剂也不足以阻止心脑血管猝死综合症的传播。然而，通过将杀螨剂控制与牲畜疫苗接种相结合，可显著减少疾病传播，并在某些情况下消除疾病。总之，研究结果表明，了解综合防治策略的影响对于缓解这种毁灭性牲畜疾病的传播以及加强决策者和牲畜饲养者的决策至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Parasite Epidemiology and Control Medicine-Infectious Diseases

CiteScore

5.70

自引率

3.10%

发文量

审稿时长

17 weeks

期刊介绍： Parasite Epidemiology and Control is an Open Access journal. There is an increasing amount of research in the parasitology area that analyses the patterns, causes, and effects of health and disease conditions in defined populations. This epidemiology of parasite infectious diseases is predominantly studied in human populations but also spans other major hosts of parasitic infections and as such this journal will have a broad remit. We will focus on the major areas of epidemiological study including disease etiology, disease surveillance, drug resistance and geographical spread and screening, biomonitoring, and comparisons of treatment effects in clinical trials for both human and other animals. We will also look at the epidemiology and control of vector insects. The journal will also cover the use of geographic information systems (Epi-GIS) for epidemiological surveillance which is a rapidly growing area of research in infectious diseases. Molecular epidemiological approaches are also particularly encouraged.