{"title":"Enter the Matrix: An Update on MALDI-ToF MS Advancements through 2024","authors":"John A. Fissel","doi":"10.1016/j.clinmicnews.2024.05.001","DOIUrl":null,"url":null,"abstract":"<div><p>MALDI-ToF MS has become a cornerstone of the clinical microbiology laboratory. The reliability and ease-of-use of these instruments make them a popular choice of study to expand their applications and increase efficiency. The use of artificial intelligence has rapidly expanded in recent years and efforts are underway to integrate this technology into the clinical microbiology laboratory to expand the applications of MALDI-ToF MS and advance beyond current limitations in the identification of clinical isolates. At the same time as the rise of AI, clinical laboratories are facing pressure to increase efficiency due to the critical shortage of qualified laboratory personnel. Studies examining the performance of simplified testing workflows seek to help laboratorians do more with less. The improvement and creation of additional databases is also improving the rate of successful identifications. This review seeks to provide an update on recent developments around these topics.</p></div>","PeriodicalId":39211,"journal":{"name":"Clinical Microbiology Newsletter","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0196439924000163/pdfft?md5=c6740b41df7c838c2077718e4a4d970f&pid=1-s2.0-S0196439924000163-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Microbiology Newsletter","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0196439924000163","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
MALDI-ToF MS has become a cornerstone of the clinical microbiology laboratory. The reliability and ease-of-use of these instruments make them a popular choice of study to expand their applications and increase efficiency. The use of artificial intelligence has rapidly expanded in recent years and efforts are underway to integrate this technology into the clinical microbiology laboratory to expand the applications of MALDI-ToF MS and advance beyond current limitations in the identification of clinical isolates. At the same time as the rise of AI, clinical laboratories are facing pressure to increase efficiency due to the critical shortage of qualified laboratory personnel. Studies examining the performance of simplified testing workflows seek to help laboratorians do more with less. The improvement and creation of additional databases is also improving the rate of successful identifications. This review seeks to provide an update on recent developments around these topics.
MALDI-ToF MS 已成为临床微生物实验室的基石。这些仪器的可靠性和易用性使其成为扩大应用和提高效率的热门研究选择。近年来，人工智能的使用范围迅速扩大，人们正在努力将这一技术融入临床微生物学实验室，以扩大 MALDI-ToF MS 的应用范围，并超越目前在鉴定临床分离物方面的局限性。在人工智能兴起的同时，由于合格的实验室人员严重短缺，临床实验室也面临着提高效率的压力。对简化检测工作流程的性能进行研究，旨在帮助实验室人员少花钱多办事。改进和创建更多数据库也在提高鉴定成功率。本综述旨在介绍围绕这些主题的最新进展。
期刊介绍：
Highly respected for its ability to keep pace with advances in this fast moving field, Clinical Microbiology Newsletter has quickly become a “benchmark” for anyone in the lab. Twice a month the newsletter reports on changes that affect your work, ranging from articles on new diagnostic techniques, to surveys of how readers handle blood cultures, to editorials questioning common procedures and suggesting new ones.
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