HIGH-RISK HPV TYPES AND PATHOLOGY RESULTS IN PATIENTS WITH HIGH-RISK HPV POSITIVE

Abstract

Aim: We aimed to analyses the high-risk HPV type distribution and pathology results in high-risk HPV positive patients. Materials and Methods: The research was retrospectively conducted and data was obtained from a tertiary gynecologic oncology colposcopy outpatient clinic. From September 2019 to December 2022, data from 3546 patients who tested positive for HPV and underwent colposcopic examination were analyzed. All patients granted the institution explicit permission to utilize their clinical data. Results: A total of 3546 patients with a median age of 40 years (range, 18–77 years) were analysed. Patient’s HPV status was; 1169 (33%) patients were HPV 16, 343 (9.7%) patients were HPV 18, and 2318 (65.4%) patients were HPV others. The detailed HPV positive results of patients were that 888 (25.4%) patients were only HPV 16, 197 (5.6%) patients were only HPV 18, and 2097 (59.9%) patients were only HPV others. In the study cohort, 529 (14.9%) patients had CIN 2+ lesions. HPV 16 and/or HPV 18 were detected in 331 (62.5%) of 529 patients with CIN 2+ lesions. The final pathology result of 507 (14.3%) patients was CIN 2/3 and of 22 (0.6%) patients was cancer. Conclusion: In conclusion, we found that while HPV other types were positive in two-thirds of the patients, HPV 16 and/or 18 were positive in more than four-fifths of the cancer cases. In the high-risk HPV positive patient group, HPV type can be used as a criterion when referring the patient to colposcopy