Comprehensive Analysis of Sphingolipid Metabolism-Related Genes in Osteoarthritic Diagnosis and Synovial Immune Dysregulation

IF 2.2 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Science Monitor Pub Date : 2024-05-06 DOI:10.12659/msm.943369

Zheng Zhu, Bizhi Tu, Run Fang, Jun Tong, Yulong Liu, Rende Ning

引用次数: 0

Abstract

genes showed associations with immune-related cell infiltration and levels of inflammatory cytokines. Furthermore, we observed heterogeneity in the expression patterns of hub genes across different clusters of OA. Notably, older patients displayed increased susceptibility to elevated levels of pain-related inflammatory cytokines and infiltration of immune cells. Conclusions: The SMP-related hub genes have the potential to serve as diagnostic markers for OA patients. Moreover, the 4 hub genes of SMP demonstrate wide participation in immune dysregulation in OA synovium. The activation of different pathways is observed among different populations of patients with OA.

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全面分析骨关节炎诊断和滑膜免疫失调中的鞘脂代谢相关基因

这些基因与免疫相关细胞浸润和炎症细胞因子水平有关。此外，我们还观察到 OA 不同群组中枢基因表达模式的异质性。值得注意的是，老年患者更容易出现疼痛相关炎性细胞因子水平升高和免疫细胞浸润。结论与 SMP 相关的枢纽基因有可能成为 OA 患者的诊断标志物。此外，SMP 的 4 个枢纽基因广泛参与了 OA 滑膜的免疫失调。在不同的 OA 患者人群中观察到了不同途径的激活。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Science Monitor 医学-医学：研究与实验

自引率

3.20%

发文量

514

审稿时长

3 months

期刊介绍： Medical Science Monitor (MSM) established in 1995 is an international, peer-reviewed scientific journal which publishes original articles in Clinical Medicine and related disciplines such as Epidemiology and Population Studies, Product Investigations, Development of Laboratory Techniques :: Diagnostics and Medical Technology which enable presentation of research or review works in overlapping areas of medicine and technology such us (but not limited to): medical diagnostics, medical imaging systems, computer simulation of health and disease processes, new medical devices, etc. Reviews and Special Reports - papers may be accepted on the basis that they provide a systematic, critical and up-to-date overview of literature pertaining to research or clinical topics. Meta-analyses are considered as reviews. A special attention will be paid to a teaching value of a review paper. Medical Science Monitor is internationally indexed in Thomson-Reuters Web of Science, Journals Citation Report (JCR), Science Citation Index Expanded (SCI), Index Medicus MEDLINE, PubMed, PMC, EMBASE/Excerpta Medica, Chemical Abstracts CAS and Index Copernicus.