REVITALIZING THERAPEUTICS: DRUG REPURPOSING AS A COST-EFFECTIVE STRATEGY FOR DRUG DEVELOPMENT

Q2 Pharmacology, Toxicology and Pharmaceutics

International Journal of Applied Pharmaceutics Pub Date : 2024-05-07 DOI:10.22159/ijap.2024v16i3.49581

Shivani Makhijani

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引用次数: 0

Abstract

The process of developing new drugs is known for being drawn-out, expensive, risky, and having a high attrition rate. Drug repurposing has grown in favor recently as a practical way to speed up the development of new medicines while reducing the costs and time constraints associated with traditional drug research. The description of this study's pharmacological repurposing highlights its promise as a practical method to fill gaps in the market and revitalize treatment options. This review provides a full analysis of the ground-breaking tactic of repurposing medications, supported by numerous cases that demonstrate its revolutionary potential. We examine instances of repurposed drugs, such as thalidomide, sildenafil, and metformin, that have performed astoundingly well in a range of therapeutic settings despite being used outside of their original scope. Overall, the paper's main goal-to study pharmacological repurposing as a potentially successful strategy for revitalizing treatments-is, succinctly summarized in this abstract. It highlights the potential benefits of this approach and how it might be used in the pharmaceutical industry's ongoing quest for more inexpensive and effective medicine development.

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振兴疗法：药物再利用作为一种具有成本效益的药物开发战略

众所周知，新药研发过程耗时长、成本高、风险大、损耗率高。近来，药物再利用作为一种既能加快新药开发，又能减少传统药物研究成本和时间限制的实用方法，越来越受到人们的青睐。本研究对药物再利用的描述突出了其作为填补市场空白和振兴治疗方案的实用方法的前景。本综述全面分析了药物再利用这一突破性策略，并通过大量案例证明了其革命性潜力。我们研究了沙利度胺、西地那非和二甲双胍等再利用药物的实例，尽管这些药物的使用超出了其原有的范围，但它们在一系列治疗环境中的表现却令人震惊。总之，本文的主要目标--研究药物再利用作为振兴疗法的潜在成功策略--在本摘要中得到了简明扼要的概括。总之，本摘要简明扼要地概括了论文的主要目标--研究药理再利用作为振兴治疗方法的潜在成功策略，强调了这种方法的潜在益处，以及如何将其用于制药业正在进行的寻求更廉价、更有效药物的开发过程中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Applied Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.40

自引率

0.00%

发文量

219

期刊介绍： International Journal of Applied Pharmaceutics (Int J App Pharm) is a peer-reviewed, bimonthly (onward March 2017) open access journal devoted to the excellence and research in the pure pharmaceutics. This Journal publishes original research work that contributes significantly to further the scientific knowledge in conventional dosage forms, formulation development and characterization, controlled and novel drug delivery, biopharmaceutics, pharmacokinetics, molecular drug design, polymer-based drug delivery, nanotechnology, nanocarrier based drug delivery, novel routes and modes of delivery; responsive delivery systems, prodrug design, development and characterization of the targeted drug delivery systems, ligand carrier interactions etc. However, the other areas which are related to the pharmaceutics are also entertained includes physical pharmacy and API (active pharmaceutical ingredients) analysis. The Journal publishes original research work either as a Original Article or as a Short Communication. Review Articles on a current topic in the said fields are also considered for publication in the Journal.