EFFICIENCY OF THE DRUG SUPERPYRIN IN THE COMPLEX APPLICATION IN THE TREATMENT OF BROILER CHICKENS

I. Kotsyumbas, O. Pyatnychko, T. Stetsko, M. Zhyla, N. Shkodyak, N. Lisova
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Abstract

The article presents the results of the study of the efficiency and safety of the drug Superpyrin, a powder for oral use, as a means of symptomatic therapy in the treatment of acute respiratory infections in broiler chickens. The active substances of the drug are acetylsalicylic, ascorbic and citric acids. The experiment was conducted on broiler chickens with clinical signs of bacterial disease – pasteurellosis. The diagnosis was made on the basis of clinical signs of the disease, the results of pathological and anatomical autopsy of dead chickens and the results of bacteriological examination of pat-material. Experimental and control groups of broiler chickens received the antimicrobial drug Doxycycline hyclate at a dose of 20 mg per kg of body weight per day orally with drinking water for 5 consecutive days. In addition to antimicrobial therapy, chickens-broiler of the experimental group received the test drug Superpyrin orally with drinking water at a dose of 1 g per 1 liter of water for 3 days. From the beginning of the treatment to the 14th day, the clinical state of the poultry of both groups was monitored, namely, the presence of adverse reactions, negative phenomena and body weight gain. Before the treatment and on the 10th day after the last administration of the drug Superpyrin, morphological and biochemical parameters of the chickens’ blood were examined. Hematological studies were conducted according to generally accepted methods, and biochemical – with the help of a semi-automatic biochemical analyzer Humalyzer 3000, using test-kits from the company Human. The obtained results were processed statistically. The results of a clinical study showed that the drug Superpyrin, a powder for oral use, in the recommended dosage, is an effective means for symptomatic therapy in the treatment of acute respiratory poultry disease of bacterial etiology. In the experimental group of chickens, the poultry mortality decreased, the treatment efficiency increased and body weight gains increased. No adverse reactions were recorded in poultry of the experimental group during the administration of the Superpyrin.
在治疗肉鸡的复合应用中超级吡咯啉药物的效率
文章介绍了对口服粉剂药物 Superpyrin 作为对症疗法治疗肉鸡急性呼吸道感染的有效性和安全性的研究结果。该药物的活性物质是乙酰水杨酸、抗坏血酸和柠檬酸。实验对象是出现细菌性疾病--巴氏杆菌病临床症状的肉鸡。诊断的依据是疾病的临床症状、死鸡的病理解剖结果和病原细菌学检查结果。实验组和对照组的肉鸡每天按每公斤体重 20 毫克的剂量口服抗菌药强力霉素(Doxycycline hyclate),连续 5 天。除抗菌药治疗外,实验组的鸡-肉鸡还以每 1 升水 1 克的剂量随饮水口服试验药物超级吡啉,连续 3 天。从治疗开始到第 14 天,监测两组家禽的临床状态,即是否出现不良反应、不良现象和体重增加情况。在治疗前和最后一次给药后的第 10 天,对鸡血液的形态和生化指标进行了检查。血液学研究是根据公认的方法进行的,而生化研究则是在半自动生化分析仪 Humalyzer 3000 的帮助下,使用 Human 公司的试剂盒进行的。所获得的结果均经过统计学处理。临床研究结果表明,按照推荐剂量口服的 Superpyrin 粉剂药物是治疗细菌性家禽急性呼吸道疾病的有效对症疗法。实验组鸡的死亡率降低,治疗效率提高,体重增加。实验组的家禽在服用 Superpyrin 期间未出现任何不良反应。
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