FRZB: a potential prognostic marker for head and neck squamous cell carcinoma

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-05-17 DOI:10.1590/1414-431X2024e13368

Yunshan Li, Feihan Gu, Xu Huang, Wenkai Huang, Junwei Xiang, Jiayuan Yue, Yuanyin Wang, Ran Chen

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引用次数: 0

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common malignancy worldwide, with approximately 600,000 new cases each year. A small number of HNSCCs are caused by human papillomavirus (HPV) infection. Frizzled related protein (FRZB) has been reported in many inflammatory diseases and cancers, but it is yet unclear how FRZB affects HNSCC, as well as its role and underlying mechanism. TIMER2 database was utilized to evaluate FRZB expression in cancer tissues, and FRZB expression in HNSCC tissues was confirmed by samples obtained from Gene Expression Omnibus. To identify whether FRZB could be used as a prognostic predictor, we performed univariate and multivariate Cox regression analyses. FRZB co-expression profile was explored using the LinkedOmics database, then Kyoto Encyclopedia of Genes and Genomes and Gene Ontology enrichment analyses were performed for these FRZB-related genes in HNSCC samples. Lasso regression analysis was subsequently used to screen for prognostic variables, and we determined the infiltration of immune cells in HNSCC patients to clarify the influence of FRZB on tumor immune microenvironment. At last, we assessed the association between FRZB expression and immune checkpoint gene, and compared the sensitivity of common chemotherapeutic agents. In this study, we found that FRZB was dysregulated in HNSCC tumor tissues and had a relationship with clinical parameters. The reliability and independence of FRZB as a factor in determining a patient's prognosis for HNSCC was also established. Additional investigation revealed that FRZB was linked to common immune checkpoint genes and may be implicated in immune infiltration.

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FRZB：头颈部鳞状细胞癌的潜在预后标志物

头颈部鳞状细胞癌（HNSCC）是全球第六大常见恶性肿瘤，每年新增病例约 600,000 例。少数 HNSCC 由人类乳头瘤病毒（HPV）感染引起。Frizzled相关蛋白（FRZB）在许多炎症性疾病和癌症中都有报道，但FRZB如何影响HNSCC及其作用和内在机制尚不清楚。研究人员利用 TIMER2 数据库评估了 FRZB 在癌症组织中的表达，并通过基因表达总库（Gene Expression Omnibus）中的样本确认了 FRZB 在 HNSCC 组织中的表达。为了确定FRZB是否可作为预后预测因子，我们进行了单变量和多变量Cox回归分析。我们利用LinkedOmics数据库探索了FRZB的共表达谱，然后对HNSCC样本中与FRZB相关的基因进行了京都基因组百科全书和基因本体富集分析。随后，我们利用拉索回归分析筛选预后变量，并测定了HNSCC患者的免疫细胞浸润情况，以明确FRZB对肿瘤免疫微环境的影响。最后，我们评估了FRZB表达与免疫检查点基因的关联，并比较了常见化疗药物的敏感性。本研究发现，FRZB在HNSCC肿瘤组织中表达失调，并与临床指标相关。我们还确定了 FRZB 作为 HNSCC 患者预后判断因素的可靠性和独立性。进一步的研究发现，FRZB 与常见的免疫检查点基因相关，可能与免疫浸润有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.