Effects of glucagon-like peptide-1 receptor agonists on gastric mucosal visibility and retained gastric contents during EGD

IF 6.7 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Gastrointestinal endoscopy Pub Date : 2024-11-01 DOI:10.1016/j.gie.2024.05.012

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Abstract

Background and Aims

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are increasingly used in diabetes and obesity management. Although GLP-1RAs delay gastric emptying, their impact on visibility during EGD remains uncertain.

Methods

A 1:1 matched case-control study was conducted. Individuals undergoing EGD who were taking GLP-1RAs were matched to nonusers based on demographic characteristics and diabetes status. A validated scale (POLPREP) was used to determine gastric mucosal visibility scores.

Results

A total of 84 pairs (N = 168) were included. GLP-1RA users had significantly lower visibility scores, with a 2.42 times higher likelihood of lower scores compared with nonusers. In addition, GLP-1RA users had a higher incidence of retained gastric contents (13.1% vs 4.8%; adjusted odds ratio, 4.62; P = .025) and aborted procedures due to this issue. No anesthesia-related adverse events were observed.

Conclusions

GLP-1RA use at the time of endoscopy exhibited higher odds of lower gastric mucosal visibility scores, retained contents, and aborted procedures. Further research is warranted.

Abstract Image

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胰高血糖素样肽-1 受体激动剂对食管胃十二指肠镜检查中胃黏膜可见度和残留胃内容物的影响

背景和目的：胰高血糖素样肽-1 受体激动剂（GLP-1RA）越来越多地被用于糖尿病和肥胖症的治疗。GLP-1RA 可延缓胃排空，但其对食管胃十二指肠镜检查（EGD）中可见度的影响仍不确定：方法：进行了一项 1:1 匹配病例对照研究。方法：进行了一项 1:1 匹配病例对照研究，根据人口统计学和糖尿病状况，将使用 GLP-1RAs 进行胃肠镜检查的患者与未使用者进行匹配。研究采用了一个经过验证的量表（POLPREP）来确定胃黏膜可见度评分：结果：共纳入 84 对配对（n=168）。GLP-1RA使用者的可见度得分明显较低，与非使用者相比，得分较低的可能性高出2.54倍。此外，GLP-1RA 使用者胃内容物残留的发生率更高（13.1% vs. 4.8%，aOR:4.62, p=0.025），并因此中止了手术。没有观察到与麻醉相关的不良事件：结论：在进行内镜检查时使用 GLP-1RA 会导致胃黏膜能见度评分降低、内容物滞留和手术流产的几率增加。值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastrointestinal endoscopy 医学-胃肠肝病学

CiteScore

10.30

自引率

7.80%

发文量

1441

审稿时长

38 days

期刊介绍： Gastrointestinal Endoscopy is a journal publishing original, peer-reviewed articles on endoscopic procedures for studying, diagnosing, and treating digestive diseases. It covers outcomes research, prospective studies, and controlled trials of new endoscopic instruments and treatment methods. The online features include full-text articles, video and audio clips, and MEDLINE links. The journal serves as an international forum for the latest developments in the specialty, offering challenging reports from authorities worldwide. It also publishes abstracts of significant articles from other clinical publications, accompanied by expert commentaries.