Prevalence of Age-Related Macular Degeneration in Patients with Chronic Exposure to P2X7R Inhibitors.

IF 2.4 3区 医学 Q2 OPHTHALMOLOGY
Kwang Min Woo, M Abdallah Mahrous, Donald J D'Amico, Szilard Kiss, Kyle D Kovacs
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引用次数: 0

Abstract

Purpose: P2X7 receptor (P2X7R) is a purinergic cation channel whose activation has been linked with age-related macular degeneration (ARMD). Several nucleoside reverse transcriptase inhibitors, zidovudine (AZT), lamivudine (3TC) and abacavir (ABC), have been shown to inhibit P2X7R and improve outcomes in animal models of ARMD. Our aim is to investigate the association between chronic AZT, 3TC, and ABC therapy and ARMD in a clinical setting.

Methods: This is a retrospective cohort study comparing 445 patients with HIV and confirmed usage of AZT, 3TC, and ABC against 200 patients with HIV without usage of AZT, 3TC, and ABC and 445 non-HIV infected patients. Fundus examination and spectral domain optical coherence tomography (SD-ODT) were used to measure prevalence of early-intermediate stage ARMD, geographic atrophy, and exudative ARMD.

Results: There was no statistically significant difference in the prevalence of early-intermediate stage ARMD between the HIV infected patients with a history of AZT, 3TC, and ABC use and the HIV infected patients without AZT, 3TC, and ABC use (p = 0.887). There was also no statistically significant difference in the prevalence of geographical atrophy (p = 0.062) and exudative AMD (p > 0.999) between the HIV infected patients with a history of AZT, 3TC, and ABC use and non-HIV infected patients.

Conclusion: We did not find an effect of P2X7R inhibiting antiretrovirals usage on early-intermediate stage ARMD, geographical atrophy, or exudative ARMD. Studies with larger cohort and more rigorous medication history are needed to assess the effects on geographical atrophy or exudative ARMD.

Abstract Image

长期暴露于 P2X7R 抑制剂的患者中老年性黄斑变性的患病率。
目的:P2X7 受体(P2X7R)是一种嘌呤能阳离子通道,其激活与年龄相关性黄斑变性(ARMD)有关。齐多夫定(AZT)、拉米夫定(3TC)和阿巴卡韦(ABC)等几种核苷类逆转录酶抑制剂已被证明可抑制 P2X7R 并改善 ARMD 动物模型的预后。我们的目的是在临床环境中研究慢性 AZT、3TC 和 ABC 治疗与 ARMD 之间的关联:这是一项回顾性队列研究,比较了 445 名确诊使用过 AZT、3TC 和 ABC 的 HIV 感染者与 200 名未使用过 AZT、3TC 和 ABC 的 HIV 感染者以及 445 名非 HIV 感染者。眼底检查和光谱域光学相干断层扫描(SD-ODT)用于测量早期-中期ARMD、地理萎缩和渗出性ARMD的患病率:曾使用过 AZT、3TC 和 ABC 的艾滋病病毒感染者与未使用过 AZT、3TC 和 ABC 的艾滋病病毒感染者的早中期 ARMD 患病率差异无统计学意义(p = 0.887)。有 AZT、3TC 和 ABC 使用史的艾滋病病毒感染者与未感染艾滋病病毒的患者在地理萎缩(p = 0.062)和渗出性黄斑变性(p > 0.999)的患病率方面也没有统计学意义上的差异:我们没有发现使用 P2X7R 抑制性抗逆转录病毒药物对早中期 ARMD、地域性萎缩或渗出性 ARMD 有影响。要评估对地域性萎缩或渗出性 ARMD 的影响,需要进行更大规模的队列研究和更严格的用药史研究。
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来源期刊
CiteScore
5.40
自引率
7.40%
发文量
398
审稿时长
3 months
期刊介绍: Graefe''s Archive for Clinical and Experimental Ophthalmology is a distinguished international journal that presents original clinical reports and clini-cally relevant experimental studies. Founded in 1854 by Albrecht von Graefe to serve as a source of useful clinical information and a stimulus for discussion, the journal has published articles by leading ophthalmologists and vision research scientists for more than a century. With peer review by an international Editorial Board and prompt English-language publication, Graefe''s Archive provides rapid dissemination of clinical and clinically related experimental information.
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