Nutrition, Other Environmental Influences, and Genetics in the Determination of Human Stature.

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS
Annual review of nutrition Pub Date : 2024-08-01 Epub Date: 2024-08-12 DOI:10.1146/annurev-nutr-061121-091112
Julian C Lui, Amanda C Palmer, Parul Christian
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引用次数: 0

Abstract

Linear growth during three distinct stages of life determines attained stature in adulthood: namely, in utero, early postnatal life, and puberty and the adolescent period. Individual host factors, genetics, and the environment, including nutrition, influence attained human stature. Each period of physical growth has its specific biological and environmental considerations. Recent epidemiologic investigations reveal a strong influence of prenatal factors on linear size at birth that in turn influence the postnatal growth trajectory. Although average population height changes have been documented in high-income regions, stature as a complex human trait is not well understood or easily modified. This review summarizes the biology of linear growth and its major drivers, including nutrition from a life-course perspective, the genetics of programmed growth patterns or height, and gene-environment interactions that determine human stature in toto over the life span. Implications for public health interventions and knowledge gaps are discussed.

营养、其他环境影响和遗传在人类身材决定中的作用。
人一生中有三个不同阶段的线性生长决定了成年后的身材:即子宫内、产后早期、青春期和青少年时期。个体宿主因素、遗传和环境(包括营养)都会影响人的身材。身体发育的每个时期都有其特定的生物和环境因素。最近的流行病学调查显示,产前因素对出生时的线性体型有很大影响,而这些因素又反过来影响产后的生长轨迹。虽然高收入地区的人口平均身高变化已被记录在案,但人们对身材这一复杂的人类特征并不十分了解,也不容易改变。本综述总结了线性生长的生物学及其主要驱动因素,包括从生命过程的角度看营养、程序化生长模式或身高的遗传学,以及决定人一生身材的基因与环境的相互作用。讨论了公共卫生干预措施的意义和知识差距。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
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