National epidemiology of digital papillary adenocarcinoma in England 2013-2020: a population-based registry study.

IF 3.7 4区 医学 Q1 DERMATOLOGY
Kashini Andrew, Birgitta van Bodegraven, Sally Vernon, Mariam Balogun, Paul Craig, Neil Rajan, Zoe C Venables, Simon Tso
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引用次数: 0

Abstract

Background: Digital papillary adenocarcinoma (DPA), formerly known as aggressive DPA, is a rare adnexal cancer of sweat gland differentiation with metastatic potential. DPA epidemiology and patient outcome data are prerequisites for developing diagnostic and therapeutic guidance, which are lacking for this rare cancer.

Objectives: To report the incidence, patient demographics and treatment of patients with DPA in England from 1 January 2013 to 31 December 2020 using national cancer registry data.

Methods: DPA diagnoses in England during 2013-2020 were identified from the National Cancer Registration and Analysis Service dataset using morphology and behaviour codes. These were registered from routinely collected pathology reports, along with cancer outcomes and services datasets. The 2013 European age-standardized incidence rates (EASRs) were calculated.

Results: In total, 36 cases of DPA (7 in women and 29 in men) were diagnosed. The median age at diagnosis for the cohort was 54 years (interquartile range 46-64). The most frequently affected sites were the upper limbs (81%). All patients in the cohort received surgical excisions. The EASR was 0.10 (95% confidence interval 0.07-0.14) per 1 000 000 person-years.

Conclusions: This study reports the incidence and variation of DPA in England between 2013 and 2020. DPA was more common in older men and predominantly affected the upper limbs. This finding supports the need to develop a national policy for the reporting and management of DPA as well as development of a clinical guideline.

2013-2020 年英格兰全国数字乳头状腺癌流行病学:基于人口的登记研究。
背景:数字乳头状腺癌(DPA),以前称为侵袭性 DPA,是一种罕见的汗腺分化型附件癌症,具有转移潜力。DPA流行病学和患者预后数据是制定诊断和治疗指南的先决条件,而这种罕见癌症目前还缺乏这方面的数据:利用国家癌症登记数据,报告 2013 年 1 月 1 日至 2020 年 12 月 31 日期间英格兰 DPA 患者的发病率、患者人口统计学特征和治疗情况:方法:使用形态学和行为学代码从全国癌症登记数据集中确定 2013-2020 年期间英格兰的 DPA 诊断病例。这些数据来自常规收集的病理报告以及癌症结果和服务数据集。计算了2013年欧洲年龄标准化发病率(EASR):共诊断出 36 例 DPA(女性 7 例,男性 29 例)。队列中确诊年龄的中位数为 54 岁(四分位数间距为 46-64)。最常受影响的部位是上肢(81%)。队列中的所有患者均接受了手术切除。欧洲年龄标准化发病率(EASRs)为每100万人年0.10[95%置信区间(CI)0.07-0.14]]:本研究报告了 2013 年至 2020 年期间英格兰 DPA 的发病率和变化情况。DPA在老年男性中更为常见,主要影响上肢。这支持了制定 DPA 报告和管理国家政策以及临床指南的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.20
自引率
2.40%
发文量
389
审稿时长
3-8 weeks
期刊介绍: Clinical and Experimental Dermatology (CED) is a unique provider of relevant and educational material for practising clinicians and dermatological researchers. We support continuing professional development (CPD) of dermatology specialists to advance the understanding, management and treatment of skin disease in order to improve patient outcomes.
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