Three-Dimensional-Printed Template-Guided Radioactive Seed Brachytherapy via a Submental Approach for Recurrent Base of Tongue and Floor of Mouth Cancer.

IF 2.1 Q3 ONCOLOGY

World Journal of Oncology Pub Date : 2024-06-01 Epub Date: 2024-05-07 DOI:10.14740/wjon1775

Zhe Ji, Yu Liang Jiang, Hai Tao Sun, Bin Qiu, Mao Li, Jing Hong Fan, Jun Jie Wang

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引用次数: 0

Abstract

Background: This study assessed clinical outcomes of three-dimensional-printed template (3DPT)-guided radioactive seed brachytherapy (RSBT) via a submental approach for recurrent base of tongue and floor of mouth cancer.

Methods: Thirty-one patients with recurrent lingual and floor of mouth squamous cell carcinoma after surgery and radiotherapy were treated with 3DPT-guided RSBT from 2015 to 2022. Seeds were implanted through a submental approach guided by 3DPTs. Local control (LC), overall survival (OS), disease control (DC) and quality of life (QOL) were evaluated.

Results: The median follow-up was 13.7 months. The 1-, 3- and 5-year LC rates were 66.1%, 66.1%, and 55.1% respectively. The 1-, 3- and 5-year OS rates were 63.4%, 33.4%, and 8.3%. The 1-, 3- and 5-year DC rates were 37.8%, 26.5%, and 21.2%. Univariate analysis showed tumor size significantly affected LC (P = 0.031). The presence of extraterritorial lesions affected DC and OS on multivariate analysis (P < 0.01). QOL improved significantly in domains of pain, swallowing, chewing, taste, and emotion after treatment compared to baseline. Four patients (13%) developed necrosis and osteoradionecrosis.

Conclusions: 3DPT-guided submental RSBT provided favorable LC and QOL for recurrent tongue/floor of mouth cancer with minimal toxicity; moreover, severe toxicity should be noted.

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三维打印模板引导放射性粒子近距离放射治疗复发性舌底癌和口底癌的门下入路。

背景：这项研究评估了三维打印模板（3DPT）引导下放射性粒子近距离放射治疗（RSBT）经耻骨下入路治疗复发性舌底癌和口底癌的临床疗效：2015年至2022年，31名手术和放疗后复发的舌底和口底鳞癌患者接受了3DPT引导的RSBT治疗。在3DPT的引导下，通过下颌骨入路植入种子。对局部控制（LC）、总生存（OS）、疾病控制（DC）和生活质量（QOL）进行了评估：中位随访时间为 13.7 个月。1年、3年和5年的LC率分别为66.1%、66.1%和55.1%。1年、3年和5年的OS率分别为63.4%、33.4%和8.3%。1年、3年和5年生存率分别为37.8%、26.5%和21.2%。单变量分析显示，肿瘤大小对 LC 有显著影响（P = 0.031）。在多变量分析中，域外病变的存在会影响直肠癌的发生率和OS（P < 0.01）。与基线相比，治疗后患者在疼痛、吞咽、咀嚼、味觉和情绪等方面的 QOL 均有明显改善。四名患者（13%）出现了坏死和骨软化：结论：3DPT引导下的RSBT为复发性舌癌/口底癌提供了良好的LC和QOL，且毒性极低；此外，应注意严重的毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Oncology ONCOLOGY-

CiteScore

6.10

自引率

15.40%

发文量

期刊介绍： World Journal of Oncology, bimonthly, publishes original contributions describing basic research and clinical investigation of cancer, on the cellular, molecular, prevention, diagnosis, therapy and prognosis aspects. The submissions can be basic research or clinical investigation oriented. This journal welcomes those submissions focused on the clinical trials of new treatment modalities for cancer, and those submissions focused on molecular or cellular research of the oncology pathogenesis. Case reports submitted for consideration of publication should explore either a novel genomic event/description or a new safety signal from an oncolytic agent. The areas of interested manuscripts are these disciplines: tumor immunology and immunotherapy; cancer molecular pharmacology and chemotherapy; drug sensitivity and resistance; cancer epidemiology; clinical trials; cancer pathology; radiobiology and radiation oncology; solid tumor oncology; hematological malignancies; surgical oncology; pediatric oncology; molecular oncology and cancer genes; gene therapy; cancer endocrinology; cancer metastasis; prevention and diagnosis of cancer; other cancer related subjects. The types of manuscripts accepted are original article, review, editorial, short communication, case report, letter to the editor, book review.

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