Clinical applications and challenges of metagenomic next-generation sequencing in the diagnosis of pediatric infectious disease

IF 1.1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY

Journal of Laboratory Medicine Pub Date : 2024-05-10 DOI:10.1515/labmed-2023-0158

Qiang Guo, Shihai Zhang

引用次数: 0

Abstract

Infectious diseases seriously threaten the lives of children. Timely and accurate detection of pathogenic microorganisms and targeted medication are the keys to the diagnosing and treatment of infectious diseases in children. The next-generation metagenomic sequencing technology has attracted great attention in infectious diseases because of its characteristics such as no culture, high throughput, short detection cycle, wide coverage, and a good application prospect. In this paper, we review the studies of metagenomic next-generation sequencing in pediatric infectious diseases and analyze the challenges of its application in pediatric diseases.

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元基因组新一代测序在儿科传染病诊断中的临床应用和挑战

传染病严重威胁着儿童的生命。及时、准确地检测病原微生物并有针对性地用药，是诊断和治疗儿童感染性疾病的关键。新一代元基因组测序技术因其无需培养、高通量、检测周期短、覆盖范围广、应用前景好等特点，在感染性疾病领域引起了极大关注。本文回顾了元基因组新一代测序技术在儿科感染性疾病中的研究，并分析了其在儿科疾病中应用所面临的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Laboratory Medicine Mathematics-Discrete Mathematics and Combinatorics

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

10 weeks

期刊介绍： The Journal of Laboratory Medicine (JLM) is a bi-monthly published journal that reports on the latest developments in laboratory medicine. Particular focus is placed on the diagnostic aspects of the clinical laboratory, although technical, regulatory, and educational topics are equally covered. The Journal specializes in the publication of high-standard, competent and timely review articles on clinical, methodological and pathogenic aspects of modern laboratory diagnostics. These reviews are critically reviewed by expert reviewers and JLM’s Associate Editors who are specialists in the various subdisciplines of laboratory medicine. In addition, JLM publishes original research articles, case reports, point/counterpoint articles and letters to the editor, all of which are peer reviewed by at least two experts in the field.