Naturally occurring and artificially designed antimicrobial peptides: a comparative study of Mastoparan C and BP52

IF 2.6 4区医学 Q3 CHEMISTRY, MEDICINAL

Medicinal Chemistry Research Pub Date : 2024-05-13 DOI:10.1007/s00044-024-03205-3

Hai Bui Thi Phuong, Yen Do Hai, Viet Nguyen Huu, Anh Luong The, Minh Nguyen Hong, Huy Luong Xuan

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Abstract

Antimicrobial peptides (AMPs) are naturally occurring molecules that play a vital role in the innate immune responses of various organisms. Additionally, artificial AMPs are also designed based on the common structure-activity relationships (SARs) found in natural ones. As part of our ongoing effort to explore the advantages of each source, this study focused on two representative helical AMPs: Mastoparan C (MPC) and BP52. While the former is derived from the venom of the European wasp Vespa crabro, the latter belongs to a group of artificially designed AMPs inspired by the structure of two natural peptides, Cecropin A and Melittin M. Our data suggests that BP52 exhibits similar antimicrobial activity to MPC but demonstrates significantly higher potency against the A427 cancer cells. Taken together with the shorter length and reduced toxicity to human red blood cells, BP52 exhibited greater potential in drug development compared to its counterpart MPC, thus highlighting the potential of rational design in developing short, potent and selective membrane-active peptides.

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天然存在和人工设计的抗菌肽：对 Mastoparan C 和 BP52 的比较研究

抗菌肽（AMPs）是天然存在的分子，在各种生物的先天免疫反应中发挥着重要作用。此外，人工 AMPs 也是根据天然 AMPs 中常见的结构-活性关系 (SAR) 设计的。作为我们不断探索各种来源优势的努力的一部分，本研究重点关注两种具有代表性的螺旋 AMP：Mastoparan C（MPC）和 BP52。我们的数据表明，BP52 与 MPC 具有相似的抗菌活性，但对 A427 癌细胞的效力明显更高。与同类的 MPC 相比，BP52 的长度更短，对人类红细胞的毒性更低，因此在药物开发方面表现出更大的潜力，从而凸显了合理设计在开发短小、强效和选择性膜活性肽方面的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicinal Chemistry Research 医学-医药化学

CiteScore

4.70

自引率

3.80%

发文量

162

审稿时长

5.0 months

期刊介绍： Medicinal Chemistry Research (MCRE) publishes papers on a wide range of topics, favoring research with significant, new, and up-to-date information. Although the journal has a demanding peer review process, MCRE still boasts rapid publication, due in part, to the length of the submissions. The journal publishes significant research on various topics, many of which emphasize the structure-activity relationships of molecular biology.