Limited predictive value of the gut microbiome and metabolome for response to biological therapy in inflammatory bowel disease

Femke M. Prins, Iwan J. Hidding, Marjolein A.Y. Klaassen, Valerie Collij, Johannes P.D. Schultheiss, Werna T.C. Uniken Venema, Amber Bangma, Jurne B. Aardema, Bernadien H. Jansen, Wout G.N. Mares, Ben J.M. Witteman, Eleonora A.M. Festen, Gerard Dijkstra, Marijn C. Visschedijk, Herma H. Fidder, Arnau Vich Vila, Bas Oldenburg, Ranko Gacesa, Rinse K. Weersma
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Abstract

Introduction The complexity of Inflammatory Bowel Diseases (IBD) presents challenges for the management of these diseases. Predicting treatment outcomes remains difficult, leading to suboptimal outcomes and high costs. Emerging evidence suggests the potential of the gut microbiome in predicting response to biologic treatments. In this prospective study we aimed to predict treatment response to vedolizumab and ustekinumab in 79 IBD patients by integrating clinical data, gut microbiome profiles and fecal metabolites and validating these findings in a replication cohort of 47 IBD patients.
肠道微生物组和代谢组对炎症性肠病生物疗法反应的预测价值有限
导言 炎症性肠病(IBD)的复杂性给这些疾病的治疗带来了挑战。预测治疗结果仍然困难重重,导致治疗效果不理想和高昂的费用。新的证据表明,肠道微生物组在预测对生物治疗的反应方面具有潜力。在这项前瞻性研究中,我们旨在通过整合临床数据、肠道微生物组图谱和粪便代谢物来预测 79 例 IBD 患者对维多利珠单抗和乌司替尼的治疗反应,并在 47 例 IBD 患者的复制队列中验证这些发现。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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