EMP1 correlated with cancer progression and immune characteristics in pan-cancer and ovarian cancer.

IF 2.3 3区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jun Zhang, Jing Yang, Xing Li, Lin Mao, Yan Zhang, Yi Liu, Yindi Bao
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引用次数: 0

Abstract

This study examines the prognostic role and immunological relevance of EMP1 (epithelial membrane protein-1) in a pan-cancer analysis, with a focus on ovarian cancer. Utilizing data from TCGA, CCLE, and GTEx databases, we assessed EMP1 mRNA expression and its correlation with tumor progression, prognosis, and immune microenvironment across various cancers. Our results indicate that EMP1 expression is significantly associated with poor prognosis in multiple cancer types, including ovarian, bladder, testicular, pancreatic, breast, brain, and uveal melanoma. Immune-related analyses reveal a positive correlation between EMP1 and immune cell infiltration, particularly neutrophils, macrophages, and dendritic cells, as well as high expression of immune checkpoint such as CD274, HAVCR2, IL10, PDCD1LG2, and TGFB1 in most tumors. In vivo experiments confirm that EMP1 promotes ovarian cancer cell proliferation, metastasis, and invasion. In conclusion, EMP1 emerges as a potential prognostic biomarker and therapeutic target in various cancers, particularly ovarian cancer, due to its influence on tumor progression and immune cell dynamics. Further research is warranted to elucidate the precise mechanisms of EMP1 in cancer biology and to translate these findings into clinical applications.

Abstract Image

EMP1与泛癌症和卵巢癌的癌症进展和免疫特征相关。
本研究通过泛癌症分析研究了 EMP1(上皮膜蛋白-1)的预后作用和免疫学相关性,重点是卵巢癌。利用来自 TCGA、CCLE 和 GTEx 数据库的数据,我们评估了 EMP1 mRNA 的表达及其与各种癌症的肿瘤进展、预后和免疫微环境的相关性。我们的研究结果表明,在多种癌症类型中,EMP1 的表达与不良预后显著相关,包括卵巢癌、膀胱癌、睾丸癌、胰腺癌、乳腺癌、脑癌和葡萄膜黑色素瘤。免疫相关分析表明,在大多数肿瘤中,EMP1 与免疫细胞浸润(尤其是中性粒细胞、巨噬细胞和树突状细胞)以及免疫检查点(如 CD274、HAVCR2、IL10、PDCD1LG2 和 TGFB1)的高表达呈正相关。体内实验证实,EMP1 能促进卵巢癌细胞的增殖、转移和侵袭。总之,由于 EMP1 对肿瘤进展和免疫细胞动态的影响,它已成为各种癌症(尤其是卵巢癌)的潜在预后生物标志物和治疗靶点。要阐明 EMP1 在癌症生物学中的确切机制并将这些发现转化为临床应用,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular Genetics and Genomics
Molecular Genetics and Genomics 生物-生化与分子生物学
CiteScore
5.10
自引率
3.20%
发文量
134
审稿时长
1 months
期刊介绍: Molecular Genetics and Genomics (MGG) publishes peer-reviewed articles covering all areas of genetics and genomics. Any approach to the study of genes and genomes is considered, be it experimental, theoretical or synthetic. MGG publishes research on all organisms that is of broad interest to those working in the fields of genetics, genomics, biology, medicine and biotechnology. The journal investigates a broad range of topics, including these from recent issues: mechanisms for extending longevity in a variety of organisms; screening of yeast metal homeostasis genes involved in mitochondrial functions; molecular mapping of cultivar-specific avirulence genes in the rice blast fungus and more.
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