Assessing Regurgitation Severity, Adverse Remodeling, and Fibrosis with CMR in Primary Mitral Regurgitation.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-07-01 Epub Date: 2024-05-15 DOI:10.1007/s11886-024-02069-8

Amr Darwish, Akila Bersali, Mujtaba Saeed, Aneesh Dhore, Dimitrios Maragiannis, K Carlos El-Tallawi, Dipan J Shah

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Abstract

Purpose of review: This review offers an evidence-based analysis of established and emerging cardiovascular magnetic resonance (CMR) techniques used to assess the severity of primary mitral regurgitation (MR), identify adverse cardiac remodeling and its prognostic effect. The aim is to provide different insights regarding clinical decision-making and enhance the clinical outcomes of patients with MR.

Recent findings: Cardiac remodeling and myocardial replacement fibrosis are observed frequently in the presence of substantial LV volume overload, particularly in cases with severe primary MR. CMR serves as a useful diagnostic imaging modality in assessing mitral regurgitation severity, early detection of cardiac remodeling, myocardial dysfunction, and myocardial fibrosis, enabling timely intervention before irreversible damage ensues. Incorporating myocardial remodeling in terms of left ventricular (LV) dilatation and myocardial fibrosis with quantitative MR severity assessment by CMR may assist in defining optimal timing of intervention.

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用 CMR 评估原发性二尖瓣反流的反流严重程度、不良重塑和纤维化。

综述目的：本综述对用于评估原发性二尖瓣反流（MR）严重程度、识别不良心脏重塑及其预后影响的成熟和新兴心血管磁共振（CMR）技术进行了循证分析。其目的是为临床决策提供不同的见解，提高二尖瓣反流患者的临床疗效：最近的研究结果：在左心室容量严重超负荷的情况下，尤其是在患有严重原发性 MR 的病例中，经常可以观察到心脏重塑和心肌替代纤维化。在评估二尖瓣反流严重程度、早期发现心脏重塑、心肌功能障碍和心肌纤维化方面，CMR 是一种有用的诊断成像方式，可在发生不可逆转的损伤之前及时进行干预。将左心室（LV）扩张和心肌纤维化方面的心肌重塑与 CMR 定量二尖瓣反流严重程度评估相结合，可能有助于确定最佳干预时机。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567