Letter to the editor: lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant Candida auris.

IF 8.4 2区 医学 Q1 IMMUNOLOGY
Emerging Microbes & Infections Pub Date : 2024-12-01 Epub Date: 2024-06-16 DOI:10.1080/22221751.2024.2356144
Meng Zhu, Hongyang Wang, Yongsheng Zhang, Fuzhen Pan
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引用次数: 0

Abstract

The study investigates the potential of lansoprazole, a proton pump inhibitor, to interfere with fungal respiration and enhance the antifungal activity of amphotericin B against multidrug-resistant Candida auris. The authors administered lansoprazole at concentrations significantly higher than typical therapeutic doses, which demonstrated promising results but also raised concerns about potential toxicity. We suggest incorporating a control group, monitoring toxicity indicators, performing pathological examinations, and conducting cellular assays to improve the study's rigor and reliability. We also highlight the need for further research into the mechanisms of lansoprazole's antifungal activity, its long-term effects on amphotericin B resistance, and potential drug-drug interactions with amphotericin B. Addressing these concerns is crucial for the clinical translation of lansoprazole as an adjuvant to amphotericin B.

致编辑的信:兰索拉唑干扰真菌呼吸,并与两性霉素B协同作用,对抗耐多药念珠菌。
该研究调查了质子泵抑制剂兰索拉唑干扰真菌呼吸并增强两性霉素 B 对耐多药念珠菌的抗真菌活性的潜力。作者使用的兰索拉唑浓度明显高于典型的治疗剂量,结果令人鼓舞,但也引发了对潜在毒性的担忧。我们建议加入对照组、监测毒性指标、进行病理检查和细胞检测,以提高研究的严谨性和可靠性。我们还强调需要进一步研究兰索拉唑的抗真菌活性机制、其对两性霉素 B 耐药性的长期影响以及与两性霉素 B 的潜在药物相互作用。
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来源期刊
Emerging Microbes & Infections
Emerging Microbes & Infections IMMUNOLOGY-MICROBIOLOGY
CiteScore
26.20
自引率
2.30%
发文量
276
审稿时长
20 weeks
期刊介绍: Emerging Microbes & Infections is a peer-reviewed, open-access journal dedicated to publishing research at the intersection of emerging immunology and microbiology viruses. The journal's mission is to share information on microbes and infections, particularly those gaining significance in both biological and clinical realms due to increased pathogenic frequency. Emerging Microbes & Infections is committed to bridging the scientific gap between developed and developing countries. This journal addresses topics of critical biological and clinical importance, including but not limited to: - Epidemic surveillance - Clinical manifestations - Diagnosis and management - Cellular and molecular pathogenesis - Innate and acquired immune responses between emerging microbes and their hosts - Drug discovery - Vaccine development research Emerging Microbes & Infections invites submissions of original research articles, review articles, letters, and commentaries, fostering a platform for the dissemination of impactful research in the field.
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