Advances on anticancer fungal metabolites: sources, chemical and biological activities in the last decade (2012–2023)

IF 4.8 3区化学 Q1 CHEMISTRY, MEDICINAL

Natural Products and Bioprospecting Pub Date : 2024-05-14 DOI:10.1007/s13659-024-00452-0

Antonio Evidente

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Abstract

Among microorganisms, fungi are the ones that have the most imagination in producing secondary metabolites with the most varied structural differences, which are produced through different biosynthetic pathways. Therefore, they synthesize secondary metabolites classifiable into numerous families of natural compounds such as amino acids, alkaloids, anthraquinones, aromatic compounds, cyclohexene epoxides, furanones, macrolides, naphthoquinones, polyketides, pyrones, terpenes, etc. They also produced metabolites with very complex structures that can not be classified in the known families of natural compounds. Many fungal metabolites show different biological activities with potential applications in agriculture, food chemistry, cosmetics, pharmacology and medicine. This review is focused on the fungal secondary metabolites with anticancer activity isolated in the last ten years. For some metabolites, when described, their biosynthetic origin, the mode of action and the results of structure activity relationships studies are also reported.

Graphical Abstract

Abstract Image

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抗癌真菌代谢物的研究进展：过去十年（2012-2023 年）的来源、化学和生物活性。

在微生物中，真菌是最具想象力的生物，它们通过不同的生物合成途径产生结构差异最大的次级代谢物。因此，它们合成的次级代谢物可分为许多天然化合物家族，如氨基酸、生物碱、蒽醌类、芳香族化合物、环己烯环氧化物、呋喃酮类、大环内酯类、萘醌类、多酮类、吡喃类、萜烯类等。它们还产生结构非常复杂的代谢物，无法归入已知的天然化合物家族。许多真菌代谢物显示出不同的生物活性，在农业、食品化学、化妆品、药理学和医学方面具有潜在的应用价值。本综述的重点是过去十年中分离出的具有抗癌活性的真菌次生代谢物。在对一些代谢物进行描述时，还将报告其生物合成来源、作用模式和结构活性关系研究结果。

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来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.