Sex-specific associations between air pollutants and asthma prevalence in Japanese adults: a population-based study.

IF 2.2 4区医学 Q3 ENVIRONMENTAL SCIENCES

International Journal of Environmental Health Research Pub Date : 2025-02-01 Epub Date: 2024-05-13 DOI:10.1080/09603123.2024.2352597

Akinori Hara, Takehiro Sato, Sara Kress, Keita Suzuki, Kim-Oanh Pham, Atsushi Tajima, Tamara Schikowski, Hiroyuki Nakamura

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Abstract

This study investigated the association between air pollutants and asthma prevalence in male and female Japanese adults. In this retrospective cross-sectional analysis, annual mean exposure levels of air pollutants, specifically nitrogen dioxide (NO2) and particulate matter with a median aerodynamic diameter ≤2.5 μm (PM2.5), were assessed at a local monitoring site. Multivariable logistic regression models, adjusted for genetic and/or lifestyle factors, were used to explore the association between air pollutants and asthma, with stratification by sex. A total of 1,497 participants aged ≥40 years were included. Their mean age was 65.9 ± 12.4 years, with 847 being women. Overall, 91 participants were diagnosed with asthma. In the multivariable model, ambient exposure levels of NO2 and PM2.5 were significantly associated with asthma in women but not in men. This study highlights sex as a significant determinant of the link between air pollutants and asthma exacerbation, particularly among female Japanese adults.

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日本成年人中空气污染物与哮喘发病率之间的性别差异：一项基于人群的研究。

这项研究调查了空气污染物与日本成年男女哮喘发病率之间的关系。在这项回顾性横断面分析中，在一个当地监测点评估了空气污染物的年平均暴露水平，特别是二氧化氮（NO2）和空气动力学直径中值≤2.5 μm的颗粒物（PM2.5）。在对遗传和/或生活方式因素进行调整后，采用多变量逻辑回归模型来探讨空气污染物与哮喘之间的关系，并按性别进行分层。共纳入了 1497 名年龄≥40 岁的参与者。他们的平均年龄为 65.9 ± 12.4 岁，其中 847 人为女性。共有 91 人被诊断患有哮喘。在多变量模型中，环境中的二氧化氮和 PM2.5 暴露水平与女性哮喘有显著相关性，但与男性无关。这项研究强调，性别是空气污染物与哮喘恶化之间联系的重要决定因素，尤其是在日本女性成年人中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Environmental Health Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.70

自引率

3.10%

发文量

134

审稿时长

>12 weeks

期刊介绍： International Journal of Environmental Health Research ( IJEHR ) is devoted to the rapid publication of research in environmental health, acting as a link between the diverse research communities and practitioners in environmental health. Published articles encompass original research papers, technical notes and review articles. IJEHR publishes articles on all aspects of the interaction between the environment and human health. This interaction can broadly be divided into three areas: the natural environment and health – health implications and monitoring of air, water and soil pollutants and pollution and health improvements and air, water and soil quality standards; the built environment and health – occupational health and safety, exposure limits, monitoring and control of pollutants in the workplace, and standards of health; and communicable diseases – disease spread, control and prevention, food hygiene and control, and health aspects of rodents and insects. IJEHR is published in association with the International Federation of Environmental Health and includes news from the Federation of international meetings, courses and environmental health issues.