Evaluation of Platelet Parameters in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma in a Background of Oral Submucous Fibrosis.

Q3 Dentistry
Indian Journal of Dental Research Pub Date : 2023-10-01 Epub Date: 2024-04-19 DOI:10.4103/ijdr.ijdr_538_23
Packiaraj Selvajothi Ranjitham, Subramanian Kuzhali, Muthu Ponnuswamy Sumathy, Santiago Gnandeepam
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引用次数: 0

Abstract

Context: The role of platelet parameters as markers of inflammation in various diseases is now in limelight. The interaction between cancer cells and platelets is a well-established phenomenon. Oral submucous fibrosis (OSMF) is a premalignant disorder with a malignant transformation rate of 2-8%. This study aimed to evaluate platelet parameters in OSMF and oral squamous cell carcinoma (OSCC) in the background of OSMF. This cross-sectional study was performed using secondary data retrieved between January 2019 and December 2019 in the Department of Oral Pathology and the Hematology Laboratory.

Methods and materials: The data retrieved included 44 histopathologically proven OSCC in a background of OSMF (group III) and 36 OSMF (group II). The haematological parameters of these selected cases were retrieved from the Sysmex XN-1000 automated hematology analyser database. A control group (group I) comprises 50 subjects with normal (negative/unflagged) haematological parameters. All data were statistically analysed using SPSS 20.0. The significance level of tests was set at 5%.

Results: The mean platelet volume (MPV) (9.60 [±0.95] P < 0.001), platelet distribution width (PDW) (10.45 [±1.9], P < 0.001), platelet large cell ratio (PLCR) (21.70 [±7.98], P < 0.001), and the ratio of mean platelet volume to total platelet count (MPV/PLT) (0.03 [0.01], P < 0.001) were lower in group III when compared to the other two groups.

Conclusions: Platelet parameters may be used as indices in the OSCC in the background of OSMF. However, large-scale prospective studies are necessary to evaluate the utility of these parameters during the malignant transformation of OSMF, thereby encouraging prompt treatment to prevent morbidity and mortality.

以口腔黏膜下纤维化和口腔鳞状细胞癌为背景的血小板参数评估
背景:血小板参数作为各种疾病中炎症的标志物,其作用目前正备受关注。癌细胞与血小板之间的相互作用是一种公认的现象。口腔黏膜下纤维化(OSMF)是一种恶性前疾病,恶变率为 2-8%。本研究旨在评估口腔黏膜下纤维化和口腔鳞状细胞癌(OSCC)背景下的血小板参数。这项横断面研究使用了2019年1月至2019年12月期间在口腔病理科和血液学实验室检索到的二手数据:检索到的数据包括 44 例经组织病理学证实的以 OSMF 为背景的 OSCC(第 III 组)和 36 例 OSMF(第 II 组)。这些选定病例的血液学参数是从 Sysmex XN-1000 自动血液分析仪数据库中提取的。对照组(第一组)包括 50 名血液学参数正常(阴性/未标记)的受试者。所有数据均使用 SPSS 20.0 进行统计分析。检验的显著性水平设定为 5%:平均血小板体积(MPV)(9.60 [±0.95] P < 0.001)、血小板分布宽度(PDW)(10.45 [±1.9], P < 0.001)、血小板大细胞比率(PLCR)(21.70 [±7.98], P < 0.001)、血小板平均体积与血小板总数之比(MPV/PLT)(0.03 [0.01],P < 0.001)与其他两组相比,III 组均较低:血小板参数可作为OSMF背景下OSCC的指标。结论:血小板参数可作为 OSMF 背景下 OSCC 的指标,但有必要进行大规模前瞻性研究,以评估这些参数在 OSMF 恶性转化过程中的效用,从而鼓励及时治疗,防止发病和死亡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Indian Journal of Dental Research
Indian Journal of Dental Research Dentistry-Dentistry (all)
CiteScore
1.80
自引率
0.00%
发文量
80
审稿时长
38 weeks
期刊介绍: Indian Journal of Dental Research (IJDR) is the official publication of the Indian Society for Dental Research (ISDR), India section of the International Association for Dental Research (IADR), published quarterly. IJDR publishes scientific papers on well designed and controlled original research involving orodental sciences. Papers may also include reports on unusual and interesting case presentations and invited review papers on significant topics.
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