[Optical coherence tomography angiography in the diagnosis of multiple sclerosis].

Q3 Medicine

Vestnik oftalmologii Pub Date : 2024-01-01 DOI:10.17116/oftalma202414002163

A Zh Fursova, M Yu Zubkova, M A Vasilyeva, Yu A Karlash, A S Derbeneva

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引用次数: 0

Abstract

Purpose: This study analyzes the main changes in retinal microcirculation in patients with multiple sclerosis (MS) and their relationship with the type of disease course.

Material and methods: 159 patients (318 eyes) were examined. The groups were formed according to the type of course and duration of MS: group 1 - 37 patients (74 eyes; 23.27%) with relapsing-remitting MS (RRMS) less than 1 year; group 2 - 47 patients (94 eyes; 29.56%) with RRMS from 1 year to 10 years; group 3 - 44 patients (86 eyes; 27.05%) with RRMS >10 years; group 4 - 32 patients (64 eyes; 20.12%) with secondary progressive MS (SPMS). Subgroups A and B were allocated within each group depending on the absence or presence of optic neuritis (ON). Patients underwent standard ophthalmological examination, including optical coherence tomography angiography (OCTA).

Results: A decrease in the vessel density (wiVD) and perfusion density (wiPD) in the macular and peripapillary regions was revealed, progressing with the duration of the disease and with its transition to the progressive type. The minimum values were observed in patients with SPMS (group 4), with the most pronounced in the subgroup with ON (wiVD = 16.06±3.65 mm/mm², wiPD = 39.38±9.46%, ppwiPD = 44.06±3.09%, ppwiF = 0.41±0.05).

Conclusion: OCTA provides the ability to detect subclinical vascular changes and can be considered a comprehensive, reliable method for early diagnosis and monitoring of MS progression.

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[光学相干断层血管造影术在多发性硬化症诊断中的应用]。

目的：本研究分析多发性硬化症（MS）患者视网膜微循环的主要变化及其与病程类型的关系。根据多发性硬化症的病程类型和持续时间分组：第1组--37名患者（74只眼；23.27%），复发缓解型多发性硬化症（RRMS）病程不足1年；第2组--47名患者（94只眼；29.56%），RRMS病程1年至10年；第3组--44名患者（86只眼；27.05%），RRMS病程大于10年；第4组--32名患者（64只眼；20.12%），继发性进展型多发性硬化症（SPMS）。根据是否患有视神经炎（ON），在每组中划分出 A 和 B 两组。患者接受了标准眼科检查，包括光学相干断层血管成像（OCTA）：结果：黄斑区和毛细血管周围的血管密度（wiVD）和灌注密度（wiPD）均有所下降，且随着病程的延长和向进行性类型的转变而下降。SPMS患者（第4组）的数值最小，ON亚组的数值最大（wiVD = 16.06±3.65 mm/mm2，wiPD = 39.38±9.46%，ppwiPD = 44.06±3.09%，ppwiF = 0.41±0.05）：OCTA能够检测亚临床血管病变，可被视为早期诊断和监测多发性硬化症进展的一种全面、可靠的方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vestnik oftalmologii Medicine-Ophthalmology

CiteScore

0.80

自引率

0.00%

发文量

129

期刊介绍： The journal publishes materials on the diagnosis and treatment of eye diseases, hygiene of vision, prevention of ophthalmic affections, history of Russian ophthalmology, organization of ophthalmological aid to the population, as well as the problems of special equipment. Original scientific articles and surveys on urgent problems of theory and practice of Russian and foreign ophthalmology are published. The journal contains book reviews on ophthalmology, information on the activities of ophthalmologists" scientific societies, chronicle of congresses and conferences.The journal is intended for ophthalmologists and scientific workers dealing with clinical problems of diseases of the eye and physiology of vision.