[Multimodal topographically oriented approach to the study of full-thickness macular holes].

Q3 Medicine

Vestnik oftalmologii Pub Date : 2024-01-01 DOI:10.17116/oftalma202414002114

T A Doktorova, A A Suetov, E V Boiko, S V Sosnovskii

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引用次数: 0

Abstract

Purpose: This article studies the relationship between structural changes according to the findings of optical coherence tomography (OCT) and OCT angiography (OCTA), microperimetry (MP), multifocal electroretinography (mfERG) parameters in topographically corresponding areas of the macular region in idiopathic full-thickness macular holes (FTMH).

Material and methods: OCT, OCTA, MP and mfERG were performed in 14 eyes with FTMH stages I-IV according to Gass. In 13 points at a distance of 0-2.5°, 2.5-5.0°, and 5.0-10.0° from the fixation point, the light sensitivity (LS), amplitude and latency of the P1 component were compared with the size of the hole, the area of cystic changes (CC) at the level of the inner nuclear layer (INL) and the outer plexiform layer and Henle fiber layer complex (OPL+HFL), vessel density in the superficial and deep capillary plexus (SCP and DCP).

Results: LS and P1 component amplitude were significantly reduced at a distance of up to 5.0° from the fixation point. LS correlates with the apical and basal diameter of the hole (R> -0.53), the area of CC in the INL (R> -0.62) and the OPL+HFL complex (R> -0.55), the density of vessels in the SCP at a distance of up to 2.5° from the fixation point (R>0.51) and in the DCP at a distance of up to 5° from the fixation point (R>0.49). The P1 amplitude correlates with the basal diameter of the hole (R= -0.38), the area of CC in the INL and the OPL+HFL complex (R> -0.33) and vessel density in the SCP (R=0.37) at a distance of up to 2.5° from the fixation point, as well as vessel density in the DCP at a distance of up to 5° from the fixation point (R=0.47). Vessel density in the DCP is significantly lower in the presence of CC in the retina (p<0.001).

Conclusion: In FTMH, there is a relationship between bioelectrical activity and LS, and structural disorders, capillary perfusion in different layers of the retina. A multimodal topographically oriented approach allows studying the relationship between structural and functional parameters in individual points of the retina and can be used in monitoring of FTMH after surgical treatment.

查看原文本刊更多论文

[以多模态地形图为导向的全厚黄斑孔研究方法]。

目的：本文研究了特发性全厚黄斑孔（FTMH）黄斑区地形相应区域的结构变化与光学相干断层扫描（OCT）、OCT血管造影（OCTA）、显微视力测定（MP）、多焦视网膜电图（mfERG）参数之间的关系：根据 Gass 标准，对 14 只 FTMH I-IV 期眼球进行了 OCT、OCTA、MP 和 mfERG 检查。在距离定点 0-2.5°、2.5-5.0° 和 5.0-10.0° 的 13 个点，将 P1 分量的光敏感度（LS）、振幅和潜伏期与眼洞大小、内核层（INL）和外丛状层及亨氏纤维层复合体（OPL+HFL）水平的囊性改变（CC）面积、浅层和深层毛细血管丛（SCP 和 DCP）的血管密度进行比较：结果：LS 和 P1 分量振幅在距离定点 5.0° 时明显减小。LS 与孔的顶端和基底直径相关（R> -0.53），与 INL 中的 CC 面积相关（R> -0.62），与 OPL+HFL 复合物相关（R> -0.55），与定点距离达 2.5° 时 SCP 中的血管密度相关（R>0.51），与定点距离达 5° 时 DCP 中的血管密度相关（R>0.49）。P1 振幅与孔的基底直径（R= -0.38）、INL 和 OPL+HFL 复合物中的 CC 面积（R> -0.33）和距定点 2.5°以内的 SCP 中的血管密度（R=0.37）以及距定点 5°以内的 DCP 中的血管密度（R=0.47）相关。视网膜中存在 CC 时，DCP 中的血管密度明显降低（p 结论：在 FTMH 中，生物电活动与 LS 之间存在关系，而结构紊乱与视网膜不同层的毛细血管灌注之间也存在关系。多模态地形图导向方法可以研究视网膜各个点的结构和功能参数之间的关系，可用于手术治疗后对 FTMH 的监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Vestnik oftalmologii Medicine-Ophthalmology

CiteScore

0.80

自引率

0.00%

发文量

129

期刊介绍： The journal publishes materials on the diagnosis and treatment of eye diseases, hygiene of vision, prevention of ophthalmic affections, history of Russian ophthalmology, organization of ophthalmological aid to the population, as well as the problems of special equipment. Original scientific articles and surveys on urgent problems of theory and practice of Russian and foreign ophthalmology are published. The journal contains book reviews on ophthalmology, information on the activities of ophthalmologists" scientific societies, chronicle of congresses and conferences.The journal is intended for ophthalmologists and scientific workers dealing with clinical problems of diseases of the eye and physiology of vision.