[Application of optical coherence tomography in the assessment of the posterior lens capsule during anti-angiogenic therapy].

Q3 Medicine

Vestnik oftalmologii Pub Date : 2024-01-01 DOI:10.17116/oftalma202414002228

L Alkharki, S N Yusef, Ya M Al-Makhdar, I V Andreeva, A G Matyuschenko, A N Gerasimov, M V Budzinskaya

{"title":"[Application of optical coherence tomography in the assessment of the posterior lens capsule during anti-angiogenic therapy].","authors":"L Alkharki, S N Yusef, Ya M Al-Makhdar, I V Andreeva, A G Matyuschenko, A N Gerasimov, M V Budzinskaya","doi":"10.17116/oftalma202414002228","DOIUrl":null,"url":null,"abstract":"Intravitreal injection (IVI) of anti-angiogenic drugs is one of the most common therapeutic procedures in ophthalmology. In recent years, a new non-contact study method has been developed - anterior segment optical coherence tomography (AS-OCT), which allows the formation of three-dimensional images of the lens and provides more detailed information about its structure and morphology.Purpose: This study uses optical coherence tomography method to analyze the risks of developing changes in the posterior lens capsule in patients after IVI of an anti-angiogenic drug.Material and methods: The study involved 100 people (14 men and 86 women) with a natural lens and neovascular age-related macular degeneration (nAMD). The average age was 70.57±7.98 years. During the study (12 months), all patients underwent IVI of an anti-angiogenic drug aflibercept in the treat-and-extend (T&E) mode. All subjects were divided into 2 groups: with a total number of IVI less than 10 - group 1 (50 patients), and more than 10 IVI - group 2 (50 patients, of which 49 were included in the study). All patients underwent OCT using the Optopol REVO NX device (Poland) with the Anterior B-scan Wide protocol before inclusion in the study, as well as after 3, 6 and 12 months.Results: It was found that the risk of developing a posterior lens capsule rupture, visualized using OCT, depends on the total number of IVI (correlation coefficient 0.473 p=0.001): the more IVI, the higher the probability that damage to the posterior capsule will occur after the next IVI, and after the 15th injection the risk of developing damage to the posterior capsule increases sharply.Conclusion: The astudy analyzed the risk factors for the development of posterior lens capsule damage that can be detected using OCT, and presented three risk groups for the development of rupture (or damage) of the posterior lens capsule depending on the number of intravitreal injections performed.","PeriodicalId":23529,"journal":{"name":"Vestnik oftalmologii","volume":"140 2. Vyp. 2","pages":"28-33"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vestnik oftalmologii","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.17116/oftalma202414002228","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Intravitreal injection (IVI) of anti-angiogenic drugs is one of the most common therapeutic procedures in ophthalmology. In recent years, a new non-contact study method has been developed - anterior segment optical coherence tomography (AS-OCT), which allows the formation of three-dimensional images of the lens and provides more detailed information about its structure and morphology.

Purpose: This study uses optical coherence tomography method to analyze the risks of developing changes in the posterior lens capsule in patients after IVI of an anti-angiogenic drug.

Material and methods: The study involved 100 people (14 men and 86 women) with a natural lens and neovascular age-related macular degeneration (nAMD). The average age was 70.57±7.98 years. During the study (12 months), all patients underwent IVI of an anti-angiogenic drug aflibercept in the treat-and-extend (T&E) mode. All subjects were divided into 2 groups: with a total number of IVI less than 10 - group 1 (50 patients), and more than 10 IVI - group 2 (50 patients, of which 49 were included in the study). All patients underwent OCT using the Optopol REVO NX device (Poland) with the Anterior B-scan Wide protocol before inclusion in the study, as well as after 3, 6 and 12 months.

Results: It was found that the risk of developing a posterior lens capsule rupture, visualized using OCT, depends on the total number of IVI (correlation coefficient 0.473 p=0.001): the more IVI, the higher the probability that damage to the posterior capsule will occur after the next IVI, and after the 15th injection the risk of developing damage to the posterior capsule increases sharply.

Conclusion: The astudy analyzed the risk factors for the development of posterior lens capsule damage that can be detected using OCT, and presented three risk groups for the development of rupture (or damage) of the posterior lens capsule depending on the number of intravitreal injections performed.

查看原文本刊更多论文

[光学相干断层扫描在抗血管生成治疗期间晶状体后囊评估中的应用]。

抗血管生成药物的玻璃体内注射（IVI）是眼科最常见的治疗方法之一。近年来，一种新的非接触式研究方法--前节光学相干断层扫描（AS-OCT）应运而生，它可以形成晶状体的三维图像，并提供有关晶状体结构和形态的更详细信息。目的：本研究采用光学相干断层扫描方法分析患者在静脉注射抗血管生成药物后晶状体后囊发生变化的风险：研究涉及100名患有天然晶状体和新生血管性年龄相关性黄斑变性（nAMD）的患者（男性14名，女性86名）。平均年龄为（70.57±7.98）岁。在研究期间（12 个月），所有患者都以治疗和延长（T&E）模式接受了抗血管生成药物 aflibercept 的静脉注射。所有受试者被分为两组：静脉滴注总次数少于10次--第1组（50名患者），静脉滴注总次数超过10次--第2组（50名患者，其中49名纳入研究）。所有患者在被纳入研究前以及3、6和12个月后，均使用Optopol REVO NX设备（波兰）进行了OCT检查，并采用了前部B扫描广角方案：研究发现，使用 OCT 观察晶状体后囊破裂的风险取决于 IVI 的总次数（相关系数 0.473 p=0.001）：IVI 次数越多，下一次 IVI 后发生后囊损伤的概率越高，第 15 次注射后发生后囊损伤的风险急剧增加：该研究分析了可通过 OCT 检测到的晶状体后囊损伤发生的风险因素，并根据玻璃体内注射的次数，提出了晶状体后囊破裂（或损伤）发生的三个风险组别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Vestnik oftalmologii Medicine-Ophthalmology

CiteScore

0.80

自引率

0.00%

发文量

129

期刊介绍： The journal publishes materials on the diagnosis and treatment of eye diseases, hygiene of vision, prevention of ophthalmic affections, history of Russian ophthalmology, organization of ophthalmological aid to the population, as well as the problems of special equipment. Original scientific articles and surveys on urgent problems of theory and practice of Russian and foreign ophthalmology are published. The journal contains book reviews on ophthalmology, information on the activities of ophthalmologists" scientific societies, chronicle of congresses and conferences.The journal is intended for ophthalmologists and scientific workers dealing with clinical problems of diseases of the eye and physiology of vision.