Photodegradation of cannabidiol (CBD) and Δ⁹-THC in cannabis plant material.

IF 2.7 3区化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Photochemical & Photobiological Sciences Pub Date : 2024-07-01 Epub Date: 2024-05-13 DOI:10.1007/s43630-024-00589-4

Arianna Bini, Sofia Salerno, Stefano Protti, Federica Pollastro, Antonella Profumo, Luca Morini, Daniele Merli

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Abstract

Δ⁹-THC, the psychotropic cannabinoid in Cannabis sativa L., for many years has been the focus of all the pharmacological attention as the main promising principle of the plant. Recently, however, cannabidiol (CBD) has brought a sudden change in the scenario, exponentially increasing the interest in pharmacology as the main non-psychotropic cannabinoid with potential therapeutic, cosmetical and clinical applications. Although the reactivity of CBD and Δ⁹-THC has been considered, little attention has been paid to the possible photodegradation of these cannabinoids in the vegetal matrix and the data available in the literature are, in some cases, contradictory. The aim of the present work is to provide a characterization of the photochemical behaviour of CBD and Δ⁹-THC in three cannabis chemotypes, namely I (Δ⁹-THC 2.50%_w/w), II (CBD:Δ⁹-THC 5.82%_w/w:3.19%_w/w) and III (CBD 3.02%_w/w).

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大麻植物材料中大麻二酚（CBD）和 Δ9-THC 的光降解。

Δ9-THC 是大麻（Cannabis sativa L.）中具有精神作用的大麻素，多年来一直是药理学关注的焦点，因为它是大麻植物中最有前途的主要成分。然而，最近大麻二酚（CBD）的出现使情况发生了突变，它作为具有潜在治疗、美容和临床应用价值的主要非精神类大麻素，成倍地提高了药理学的研究兴趣。虽然已经考虑到了 CBD 和 Δ9-THC 的反应性，但很少有人关注这些大麻素在植物基质中可能发生的光降解，而且文献中提供的数据在某些情况下相互矛盾。本研究的目的是描述 CBD 和 Δ9-THC 在三种大麻化学类型（即 I（Δ9-THC 2.50%w/w）、II（CBD:Δ9-THC 5.82%w/w:3.19%w/w）和 III（CBD 3.02%w/w）中的光化学行为特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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