Relationship between multi-pool model-based chemical exchange saturation transfer imaging, intravoxel incoherent motion MRI, and 11C-methionine uptake on PET/CT in patients with gliomas

IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Yasukage Takami , Takashi Norikane , Naruhide Kimura , Katsuya Mitamura , Yuka Yamamoto , Keisuke Miyake , Mitsuharu Miyoshi , Yoshihiro Nishiyama
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引用次数: 0

Abstract

Purpose

Magnetization transfer ratio asymmetry (MTRasym) analysis is used for chemical exchange saturation transfer (CEST) in patients with gliomas; however, this approach has limitations. CEST imaging using a multi-pool model (MPM) may allow a more detailed assessment of gliomas; however, its mechanism remains unknown. This study aimed to assess the relationship between CEST imaging by MPM, intravoxel incoherent motion (IVIM), and 11C-methionine (11C-MET) uptake on positron emission tomography/computed tomography (PET/CT) to clarify the clinical significance of CEST imaging using MPM in gliomas.

Methods

This retrospective study included 17 patients with gliomas who underwent 11C-MET PET/CT at our institution between January 2020 and January 2022. Two-dimensional axial CEST imaging was conducted using single-shot fast-spin echo acquisition at 3 T. The apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo-diffusion coefficient (D*), f, MTRasym (3.5 ppm), parameters of MPM-based CEST imaging, and tumor-to-contralateral normal brain tissue (T/N) ratio were calculated using a region-of-interest analysis. Shapiro–Wilk test, weighted kappa coefficient, and Spearman's rank correlation coefficients were used for statistical analysis.

Results

Significant correlations were found between APT_T1 and T/N ratio (ρ = 0.87, p < 0.001), APT_T2 and T/N ratio (ρ = 0.47, p < 0.05), MTRasym and T/N ratio (ρ = 0.55, p < 0.01), and T2/T1 and T/N ratio (ρ = −0.36, p < 0.05). Furthermore, significant correlations were observed between APT_T1 and ADC (ρ = −0.67, p < 0.001), APT_T1 and D (ρ = −0.70, p < 0.001), APT_T2 and D* (ρ = −0.45, p < 0.05), and T2/T1 and D (ρ = 0.39, p < 0.05).

Conclusion

These preliminary findings indicate that MPM-based CEST imaging parameters correlate with IVIM and 11C-MET uptake on PET/CT in patients with gliomas. In particular, the new parameter APT_T1 correlated more strongly with 11C-MET uptake compared to the traditional CEST parameter MTRasym.

胶质瘤患者基于多池模型的化学交换饱和转移成像、体内非相干运动磁共振成像和 PET/CT 的 11C 蛋氨酸摄取量之间的关系。
目的:磁化传递比不对称(MTRasym)分析用于胶质瘤患者的化学交换饱和传递(CEST);然而,这种方法存在局限性。使用多池模型(MPM)进行 CEST 成像可对胶质瘤进行更详细的评估;但其机制仍不清楚。本研究旨在评估 MPM 的 CEST 成像、体内非相干运动(IVIM)和正电子发射断层扫描/计算机断层扫描(PET/CT)的 11C 蛋氨酸(11C-MET)摄取量之间的关系,以明确使用 MPM 进行胶质瘤 CEST 成像的临床意义:这项回顾性研究纳入了2020年1月至2022年1月期间在我院接受11C-MET PET/CT检查的17例胶质瘤患者。二维轴向 CEST 成像采用 3 T 单次快速自旋回波采集。采用兴趣区域分析法计算了表观扩散系数(ADC)、真实扩散系数(D)、伪扩散系数(D*)、f、MTRasym(3.5 ppm)、基于 MPM 的 CEST 成像参数以及肿瘤与对侧正常脑组织(T/N)之比。统计分析采用 Shapiro-Wilk 检验、加权卡帕系数和斯皮尔曼等级相关系数:结果:APT_T1 与 T/N 比值之间存在显著相关性(ρ = 0.87,p 结论:APT_T1 与 T/N 比值之间存在显著相关性(ρ = 0.87,p 结论):这些初步研究结果表明,基于 MPM 的 CEST 成像参数与胶质瘤患者 PET/CT 上的 IVIM 和 11C-MET 摄取相关。特别是,与传统的 CEST 参数 MTRasym 相比,新参数 APT_T1 与 11C-MET 摄取的相关性更强。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Magnetic resonance imaging
Magnetic resonance imaging 医学-核医学
CiteScore
4.70
自引率
4.00%
发文量
194
审稿时长
83 days
期刊介绍: Magnetic Resonance Imaging (MRI) is the first international multidisciplinary journal encompassing physical, life, and clinical science investigations as they relate to the development and use of magnetic resonance imaging. MRI is dedicated to both basic research, technological innovation and applications, providing a single forum for communication among radiologists, physicists, chemists, biochemists, biologists, engineers, internists, pathologists, physiologists, computer scientists, and mathematicians.
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