The role of hematopoiesis in bone repair: an update.

IF 3.1 3区 医学 Q2 HEMATOLOGY
Current Opinion in Hematology Pub Date : 2024-07-01 Epub Date: 2024-05-01 DOI:10.1097/MOH.0000000000000821
Elise C Jeffery
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引用次数: 0

Abstract

Purpose of review: The repair of bone after injury requires the participation of many different immune cell populations, which are derived from the hematopoietic lineage. The field of osteoimmunology, or the study of the interactions between bone and the immune system, is a growing field with emerging impact on both the basic science and clinical aspects of fracture healing.

Recent findings: Despite previous focus on the innate immune system in fracture healing, recent studies have revealed an important role for the adaptive immune system in bone repair. The composition of adaptive and innate immune cell populations present at the fracture site is significantly altered during aging and diet-induced obesity, which may contribute to delayed healing. Recent data also suggest a complicated relationship between fracture repair and systemic inflammation, raising the possibility that immune populations from distant sites such as the gut can impact the bone repair process.

Summary: These findings have important implications for the treatment of fracture patients with antibiotics or anti-inflammatory drugs. Furthermore, the effects of systemic inflammation on fracture repair in the contexts of aging or obesity should be carefully interpreted, as they may not be uniformly detrimental.

造血在骨修复中的作用:最新进展。
综述的目的:骨损伤后的修复需要许多不同免疫细胞群的参与,这些细胞群来自造血系统。骨免疫学或骨与免疫系统之间相互作用的研究是一个不断发展的领域,对骨折愈合的基础科学和临床方面都产生了新的影响:最近的研究结果:尽管以前的研究侧重于骨折愈合中的先天性免疫系统,但最近的研究发现,适应性免疫系统在骨修复中发挥着重要作用。骨折部位的适应性免疫细胞群和先天性免疫细胞群的组成在衰老和饮食引起的肥胖过程中发生了显著变化,这可能是导致骨折延迟愈合的原因之一。最近的数据还表明,骨折修复与全身炎症之间存在复杂的关系,这就提出了一种可能性,即来自肠道等远处的免疫细胞群可能会影响骨修复过程。此外,在衰老或肥胖的情况下,全身炎症对骨折修复的影响也应仔细解读,因为这些影响可能并非都是有害的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.60
自引率
3.10%
发文量
78
审稿时长
6-12 weeks
期刊介绍: ​​​​​​​​Current Opinion in Hematology is an easy-to-digest bimonthly journal covering the most interesting and important advances in the field of hematology. Its hand-picked selection of editors ensure the highest quality selection of unbiased review articles on themes from nine key subject areas, including myeloid biology, Vascular biology, hematopoiesis and erythroid system and its diseases.
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