Cortical activation for adolescent-onset minor depression and major depressive disorder: an fNIRS study.

IF 3.6 3区医学 Q1 PSYCHIATRY

Annals of General Psychiatry Pub Date : 2024-05-09 DOI:10.1186/s12991-024-00500-6

Gaizhi Li, Ke Ma, Kathryn Rossbach, Ying Niu, Qiqi Li, Zhifen Liu, Kerang Zhang

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引用次数: 0

Abstract

Background: While depression is increasing worldwide, some patients are diagnosed as having Major Depressive Disorder (MDD), but others are diagnosed with minor depression, however, the potential neuro mechanism is unknown.

Methods: Sixty-two patients with minor depression, 44 adolescents with MDD and 54 healthy adolescents participated in this study. Functional near-infrared spectroscopy (fNIRS), both HAMD and HAMA data were collected from all of the participants.

Results: The result indicates the pervasively decreased activation of BA, 11, 21, 45 and 46 were observed in the MDD group and reduced activation of BA 45 was observed in the minor depression group. However, cortical activation was not observed between the minor depression or MDD groups. Cortical activation was also not correlated with the depressive/anxious score in the minor and MDD groups separately.

Conclusions: Cortical activation was pervasively decreased in the MDD group and slightly reduced in the minor depression group, which may be a potential neural mechanism. As reduced cortical activation in minor depression, interventions in the early stages of minor depression may help slow or even modify the development of the illness.

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青少年轻度抑郁和重度抑郁障碍的皮质激活：fNIRS 研究。

背景：抑郁症在全球范围内呈上升趋势：尽管抑郁症在全球范围内呈上升趋势，但一些患者被诊断为重度抑郁症（MDD），而另一些患者则被诊断为轻度抑郁症，然而，潜在的神经机制尚不清楚：62名轻度抑郁症患者、44名患有轻度抑郁症的青少年和54名健康青少年参加了此次研究。方法：62 名轻度抑郁症患者、44 名 MDD 青少年和 54 名健康青少年参与了这项研究，并对所有参与者进行了功能性近红外光谱（fNIRS）、HAMD 和 HAMA 数据收集：结果表明，在多发性抑郁症组观察到 BA、11、21、45 和 46 的激活普遍降低，在轻度抑郁症组观察到 BA 45 的激活降低。但是，轻度抑郁组和轻度抑郁症组之间的皮质激活程度没有差异。皮质激活与轻度抑郁组和轻度抑郁组的抑郁/焦虑评分也没有关联：结论：轻度抑郁症组的皮质激活普遍降低，而轻度抑郁症组的皮质激活则略有降低，这可能是一种潜在的神经机制。由于轻度抑郁症患者的皮质激活减少，因此在轻度抑郁症的早期阶段进行干预可能有助于减缓甚至改变病情的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of General Psychiatry PSYCHIATRY-

CiteScore

6.60

自引率

2.70%

发文量

审稿时长

>12 weeks

期刊介绍： Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.