Managing children with frequent respiratory infections and associated wheezing: a preliminary randomized study with a new multicomponent nasal spray.

IF 2.5 4区医学 Q3 ALLERGY

Allergologia et immunopathologia Pub Date : 2024-05-01 eCollection Date: 2024-01-01 DOI:10.15586/aei.v52i3.1040

Maria Angela Tosca, Attilio Varricchio, Irene Schiavetti, Matteo Naso, Valerio Damiani, Giorgio Ciprandi

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引用次数: 0

Abstract

Background: Preschoolers frequently have respiratory infections (RIs), which may cause wheezing in some subjects. Type 2 polarization may favor increased susceptibility to RIs and associated wheezing. Non-pharmacological remedies are garnering increasing interest as possible add-on therapies. The present preliminary study investigated the efficacy and safety of a new multi-component nasal spray in preschoolers with frequent RIs and associated wheezing.

Methods: Some preschoolers with these characteristics randomly took this product, containing lactoferrin, dipotassium glycyrrhizinate, carboxymethyl-beta-glucan, and vitamins C and D3 (Saflovir), two sprays per nostril twice daily for 3 months. Other children were randomly treated only with standard therapy. Outcomes included the number of RIs and wheezing episodes, use of medications, and severity of clinical manifestations.

Results: Preschoolers treated add-on with this multicomponent product experienced fewer RIs and used fewer beta-2 agonists than untreated children (P = 0.01 and 0.029, respectively).

Conclusions: This preliminary study demonstrated that a multicomponent product, administered add-on as a nasal spray, could reduce the incidence of RIs and use of symptomatic drugs for relieving wheezing in children.

查看原文本刊更多论文

治疗经常呼吸道感染并伴有喘息的儿童：新型多成分鼻腔喷雾剂的初步随机研究。

背景：学龄前儿童经常发生呼吸道感染（RIs），这可能会导致某些受试者出现喘息。2 型极化可能会增加对 RIs 和相关喘息的易感性。非药物疗法作为一种可能的附加疗法，正在引起越来越多的关注。本初步研究调查了一种新型多成分鼻腔喷雾剂对经常出现 RI 和相关喘息的学龄前儿童的有效性和安全性：一些具有上述特征的学龄前儿童随机使用了这种产品，其中含有乳铁蛋白、甘草酸二钾、羧甲基-beta-葡聚糖、维生素 C 和 D3（沙夫洛韦），每天两次，每次两个鼻孔，连续使用 3 个月。其他儿童则只随机接受标准疗法。结果包括RI和喘息发作的次数、药物使用情况和临床表现的严重程度：结果：与未接受治疗的儿童相比，接受该多组分产品附加治疗的学龄前儿童发生的 RI 和使用的 beta-2 激动剂的次数更少（P = 0.01 和 0.029）：这项初步研究表明，以鼻腔喷雾剂的形式附加使用一种多组分产品，可以降低 RI 的发生率，并减少为缓解儿童喘息而使用的对症药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergologia et immunopathologia 医学-过敏

CiteScore

3.70

自引率

0.00%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.