Single-cell proteomics by mass spectrometry: Advances and implications in cancer research

IF 3.4 4区生物学 Q2 BIOCHEMICAL RESEARCH METHODS

Proteomics Pub Date : 2024-05-10 DOI:10.1002/pmic.202300210

Yong Chiang Tan, Teck Yew Low, Pey Yee Lee, Lay Cheng Lim

引用次数: 0

Abstract

Cancer harbours extensive proteomic heterogeneity. Inspired by the prior success of single-cell RNA sequencing (scRNA-seq) in characterizing minute transcriptomics heterogeneity in cancer, researchers are now actively searching for information regarding the proteomics counterpart. Therefore recently, single-cell proteomics by mass spectrometry (SCP) has rapidly developed into state-of-the-art technology to cater the need. This review aims to summarize application of SCP in cancer research, while revealing current development progress of SCP technology. The review also aims to contribute ideas into research gaps and future directions, ultimately promoting the application of SCP in cancer research.

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质谱法单细胞蛋白质组学：癌症研究的进展和影响。

癌症具有广泛的蛋白质组异质性。此前，单细胞 RNA 测序（scRNA-seq）成功地描述了癌症中微小的转录组异质性，受此启发，研究人员现在正积极寻找与之对应的蛋白质组学信息。因此，最近质谱单细胞蛋白质组学（SCP）迅速发展成为最先进的技术，以满足这一需求。本综述旨在总结 SCP 在癌症研究中的应用，同时揭示 SCP 技术目前的发展进展。本综述旨在总结 SCP 在癌症研究中的应用，同时揭示 SCP 技术目前的发展进展，并就研究空白和未来方向提出建议，最终促进 SCP 在癌症研究中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Proteomics 生物-生化研究方法

CiteScore

6.30

自引率

5.90%

发文量

193

审稿时长

3 months

期刊介绍： PROTEOMICS is the premier international source for information on all aspects of applications and technologies, including software, in proteomics and other "omics". The journal includes but is not limited to proteomics, genomics, transcriptomics, metabolomics and lipidomics, and systems biology approaches. Papers describing novel applications of proteomics and integration of multi-omics data and approaches are especially welcome.