The EFEMEREYE Study: prenatal medication exposure and ocular anomaly occurrence in EFEMERIS health database

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-06-01 DOI:10.1016/j.jaapos.2024.103931

Charlotte Dubucs MD , Van N’Go MS , Anthony Caillet Bsc , Erika-Alejandra Cifuentes MS , Anna-Belle Beau PhD , Félix Frémont MD , Caroline Hurault-Delarue PhD , Monique Courtade-Saïdi MD, PhD , Christine Damase-Michel PharmD, PhD

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引用次数: 0

Abstract

Purpose

To describe ocular anomalies (OAs) in children and fetuses in a French general population, to estimate their prevalence, and to investigate a possible association between prenatal medication exposure and the occurrence of OA in utero or in early childhood.

Methods

We conducted a case-control study using the EFEMERIS cohort, a database containing pregnancies registered in Haute-Garonne and their outcomes. We collected OA descriptions of fetuses at the time of pregnancy termination or of children at birth and the results of eye examinations of children at 9 months and 2 years of age.

Results

The prevalence of overall OAs was 2.13%, of which 0.04% were congenital ocular malformations (COMs). A total of 2,968 cases and 136,619 controls were selected for analysis. There was a significant difference between the two groups with regard to prenatal exposure to medications for the digestive tract and metabolism, the cardiovascular system, and the respiratory system. Multivariable analysis revealed an increased risk of OA in children of mothers exposed to magnesium during and 1 month before pregnancy (OR = 1.24; 95% CI, 1.11-1.38).

Conclusions

This first pharmaco-epidemiological study on OA in France suggests that OA may be associated with exposure to commonly used medications. Given the rarity of COM, larger, international studies are warranted.

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EFEMEREYE 研究：EFEMERIS 健康数据库中的产前药物接触与眼部异常发生率。

目的：描述法国普通人群中儿童和胎儿眼部异常（OA）的情况，估计其发病率，并研究产前药物接触与子宫内或幼儿期OA发生之间可能存在的关联：我们利用 EFEMERIS 队列进行了一项病例对照研究，该队列是一个包含上加龙省登记的妊娠及其结果的数据库。我们收集了胎儿终止妊娠时或儿童出生时的OA描述，以及儿童9个月和2岁时的眼科检查结果：总体 OA 患病率为 2.13%，其中 0.04% 为先天性眼部畸形（COM）。共选取了 2 968 例病例和 136 619 例对照进行分析。在产前接触消化道和新陈代谢、心血管系统和呼吸系统药物方面，两组之间存在明显差异。多变量分析显示，母亲在怀孕期间和怀孕前1个月接触过镁的儿童患OA的风险增加（OR = 1.24; 95% CI, 1.11-1.38）：这项在法国进行的首次 OA 药物流行病学研究表明，OA 可能与接触常用药物有关。鉴于COM的罕见性，有必要进行更大规模的国际研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.