{"title":"Y-chromosomal STRs Mutation Rates in the Yakut Population","authors":"D. S. Adamov, S. A. Fedorova","doi":"10.1134/s1022795424040021","DOIUrl":null,"url":null,"abstract":"<h3 data-test=\"abstract-sub-heading\">Abstract</h3><p>The fine structure of the Y chromosome haplogroup N3a2-M1982 has been described on the basis of complete sequencing data of 23 men, indigenous residents of Yakutia, taking into account both SNP and STR mutations. The mutation rate of the Y-chromosomal STR loci in the Yakut population was calibrated using radiocarbon dating of a sample of a medieval man, Yana Young, found in the lower reaches of the Yana River in Yakutia. Our estimates of the mutation rate in 23 STR loci haplotypes of the N3a2-M1991 branch using three different calculation options (0.0032, 0.0024, 0.0032) turned out to be slightly lower than the global average value according to YHRD data (0.0033) and higher than the average “genealogical” mutation rate (0.0021), but within the confidence interval, they do not contradict modern ideas about STR mutations rate of the Y chromosome.</p>","PeriodicalId":21441,"journal":{"name":"Russian Journal of Genetics","volume":"284 1","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Genetics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1134/s1022795424040021","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
The fine structure of the Y chromosome haplogroup N3a2-M1982 has been described on the basis of complete sequencing data of 23 men, indigenous residents of Yakutia, taking into account both SNP and STR mutations. The mutation rate of the Y-chromosomal STR loci in the Yakut population was calibrated using radiocarbon dating of a sample of a medieval man, Yana Young, found in the lower reaches of the Yana River in Yakutia. Our estimates of the mutation rate in 23 STR loci haplotypes of the N3a2-M1991 branch using three different calculation options (0.0032, 0.0024, 0.0032) turned out to be slightly lower than the global average value according to YHRD data (0.0033) and higher than the average “genealogical” mutation rate (0.0021), but within the confidence interval, they do not contradict modern ideas about STR mutations rate of the Y chromosome.
期刊介绍：
Russian Journal of Genetics is a journal intended to make significant contribution to the development of genetics. The journal publishes reviews and experimental papers in the areas of theoretical and applied genetics. It presents fundamental research on genetic processes at molecular, cell, organism, and population levels, including problems of the conservation and rational management of genetic resources and the functional genomics, evolutionary genomics and medical genetics.
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