Vinuta Kamat, N R Bhavya, Boja Poojary, Veerabhadragouda B Patil, Golla Ramesh, M Mahendra
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引用次数: 0
Abstract
We have investigated the photophysical properties of chalcone derivatives by UV-visible absorption spectra. The HOMO–LUMO energies were calculated. Electrochemical properties of the compounds (5a–5d) via cyclic voltammetry showed that compounds have oxidation peaks. In addition, chalcone derivatives were analyzed for DNA binding study. It revealed that chalcone derivatives had a promising affinity towards DNA double helix. DNA binding constants of the complexes indicate the intercalative binding mode involving a strong aromatic chromophore and DNA base pairs.
Graphical Abstract
Synopsis: We have calculated the photophysical and electrochemical properties of chalcone derivatives by UV-visible absorption spectra. Along with this DNA binding studies were also performed.
我们通过紫外可见吸收光谱研究了查尔酮衍生物的光物理特性。计算了 HOMO-LUMO 能量。通过循环伏安法研究了化合物（5a-5d）的电化学性质，结果表明化合物具有氧化峰。此外，还对查尔酮衍生物进行了 DNA 结合研究。结果表明，查尔酮衍生物对 DNA 双螺旋具有良好的亲和力。复合物的 DNA 结合常数表明，强芳香发色团与 DNA 碱基对之间存在插层结合模式。图解摘要简要说明：我们通过紫外可见吸收光谱计算了查尔酮衍生物的光物理和电化学性质。同时还进行了 DNA 结合研究。
期刊介绍：
Journal of Chemical Sciences is a monthly journal published by the Indian Academy of Sciences. It formed part of the original Proceedings of the Indian Academy of Sciences – Part A, started by the Nobel Laureate Prof C V Raman in 1934, that was split in 1978 into three separate journals. It was renamed as Journal of Chemical Sciences in 2004. The journal publishes original research articles and rapid communications, covering all areas of chemical sciences. A significant feature of the journal is its special issues, brought out from time to time, devoted to conference symposia/proceedings in frontier areas of the subject, held not only in India but also in other countries.
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