A Convergent Approach to the Forskolin Skeleton

IF 1.7 4区化学 Q3 CHEMISTRY, ORGANIC

Synlett Pub Date : 2024-05-06 DOI:10.1055/s-0043-1774864

Fortune O. Ononiwu, Bo Wang, Nancy I. Totah

引用次数: 0

Abstract

A convergent approach to the forskolin skeleton is described. Assembly of a simplified tricyclic framework is achieved in a single step via the dihydropyrone Diels–Alder reaction. Selective manipulation of the resulting cycloadduct, in conjunction with an unusual equilibration of the C8 stereocenter, provides access to scaffolds that differ in relative stereochemistry at both the A/B and B/C ring junctions.

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福斯科林骨架的聚合方法

本研究介绍了一种研究福斯克林骨架的聚合方法。通过二氢吡喃酮 Diels-Alder 反应，只需一步就能组装出简化的三环框架。选择性地操纵所产生的环加载产物，再加上 C8 立体中心的不寻常平衡，就可以获得在 A/B 和 B/C 环连接处具有不同相对立体化学性质的支架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synlett 化学-有机化学

CiteScore

3.40

自引率

5.00%

发文量

369

审稿时长

1 months

期刊介绍： SYNLETT is an international journal reporting research results and current trends in chemical synthesis in short personalized reviews and preliminary communications. It covers all fields of scientific endeavor that involve organic synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines and offers the possibility to publish scientific primary data.