{"title":"The Effect of Taxifolin, a Conjugate of Taxifolin with Glyoxylic Acid, and Naringenin on the Functional Activity of Neutrophils","authors":"V. S. Shubina, M. I. Kobyakova, Yu. V. Shatalin","doi":"10.1134/S0006350923050275","DOIUrl":null,"url":null,"abstract":"<p>The aim of this work was to study the effect of taxifolin, a conjugate of taxifolin with glyoxalic acid, and naringenin on the phagocytosis of latex beads by neutrophils and the adhesive properties of these cells. It has been shown that taxifolin did not affect the phagocytic activity and adhesive properties of neutrophils. The conjugate of taxifolin with glyoxylic acid significantly inhibited the phagocytic activity of neutrophils. The conjugate also significantly enhanced the adhesion of these cells. Naringenin reduced the phagocytic activity of neutrophils, however, to a lesser extent than the conjugate. Naringenin also inhibited the adhesion of neutrophils. The data obtained indicate that polyphenols can affect the functional activity of neutrophils; this effect can play an important role in modulating the inflammatory process, in particular when prolonged activation of neutrophils leads to damage of the body’s own cells and tissues.</p>","PeriodicalId":493,"journal":{"name":"Biophysics","volume":"68 5","pages":"772 - 778"},"PeriodicalIF":4.0330,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biophysics","FirstCategoryId":"4","ListUrlMain":"https://link.springer.com/article/10.1134/S0006350923050275","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
The aim of this work was to study the effect of taxifolin, a conjugate of taxifolin with glyoxalic acid, and naringenin on the phagocytosis of latex beads by neutrophils and the adhesive properties of these cells. It has been shown that taxifolin did not affect the phagocytic activity and adhesive properties of neutrophils. The conjugate of taxifolin with glyoxylic acid significantly inhibited the phagocytic activity of neutrophils. The conjugate also significantly enhanced the adhesion of these cells. Naringenin reduced the phagocytic activity of neutrophils, however, to a lesser extent than the conjugate. Naringenin also inhibited the adhesion of neutrophils. The data obtained indicate that polyphenols can affect the functional activity of neutrophils; this effect can play an important role in modulating the inflammatory process, in particular when prolonged activation of neutrophils leads to damage of the body’s own cells and tissues.
BiophysicsBiochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
1.20
自引率
0.00%
发文量
67
期刊介绍：
Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.
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