EVALUATION OF THE ASSOCIATION OF TUMOR BIOMARKERS WITH CHILDHOOD CANCERS

IF 1.8 Q3 HEMATOLOGY

Hematology, Transfusion and Cell Therapy Pub Date : 2024-05-01 DOI:10.1016/j.htct.2024.04.043

Şule ÇALIŞKAN KAMIŞ , Metin ÇİL , Begül YAĞCI KÜPELİ

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Abstract

Objective

We aimed to investigate the indications for Carbohydrate antigen 19-9 (CA 19-9), carbohydrate antigen 125 (CA-125), carbohydrate antigen 15-3 (CA15-3) and carcinoembryogenic antigen (CEA) tumor biomarkers, less commonly used in children, and their association with patients diagnosed with childhood cancers.

Methodology

The study aimed to include patients aged 0-18 who had CA 19-9, CA-125, CA 15-3 and CEA tumor biomarker assessments at Adana City Training and Research Hospital (ACTRH) between 01.11.2022 and 01.11.2023. CA 19-9, CA-125, CA 15-3 and CEA values were recorded from routinely collected serum/blood samples of the patients. The relationship between tumor biomarkers and patients diagnosed with childhood cancers was evaluated.

Results

The study included 211 patients. Out of 211 patients, 145 (68.7%) were female, and 66 (31.3%) were male. Malignancy was detected in 35 patients (16.6%). There was no statistically significant relationship observed between CA 15-3, CA 19-9, and CEA positivity and the detection of malignancy. The respective p-values were found to be (p=0.711, p= 0.533, p=0.573). A statistically significant relationship was observed between CA-125 positivity and the detection of malignancy (p=0.002).

Conclusion

Tumor markers alone are not sufficient for making a definitive diagnosis or determining treatment decisions. However further comprehensive studies are needed for detection of association conventional tumor markers and childhood cancers.

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评估肿瘤生物标志物与儿童癌症的关系

目的我们旨在调查儿童较少使用的碳水化合物抗原 19-9 (CA19-9)、碳水化合物抗原 125 (CA-125)、碳水化合物抗原 15-3 (CA15-3) 和癌胚抗原 (CEA) 肿瘤生物标志物的适应症及其与确诊儿童癌症患者的关联。方法该研究旨在纳入2022年11月1日至2023年11月1日期间在阿达纳市培训与研究医院（ACTRH）接受CA 19-9、CA-125、CA 15-3和CEA肿瘤生物标志物评估的0-18岁患者。CA 19-9、CA-125、CA 15-3和CEA的值记录自患者常规采集的血清/血液样本。研究评估了肿瘤生物标志物与儿童癌症患者之间的关系。在211名患者中，145名（68.7%）为女性，66名（31.3%）为男性。35名患者（16.6%）发现了恶性肿瘤。CA 15-3、CA 19-9和CEA阳性与恶性肿瘤的检出率之间没有统计学意义上的显著关系。P值分别为（P=0.711、P= 0.533、P=0.573）。CA-125阳性与恶性肿瘤的检出之间有统计学意义（P=0.002）。然而，要检测常规肿瘤标志物与儿童癌症之间的关系，还需要进一步的综合研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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