Prognostic value and immunological role of MMRN1: a rising star in cancer.

IF 1.1 4区生物学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nucleosides, Nucleotides & Nucleic Acids Pub Date : 2024-05-07 DOI:10.1080/15257770.2024.2335680

Qing Zhou, Ying Liu, Jieyu Zhou, Wenling Zhang

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引用次数: 0

Abstract

Background: Multimerin 1 (MMRN1) is a factor V binding protein, which can support platelet adhesion and thrombus formation. In recent years, the role of MMRN1 in cancer has begun to attract attention. But systematic studies in this area are lacking. Therefore, we used bioinformatics methods to analyze MMRN1 in tumors to reveal the possible role of MMRN1.

Methods: Using the Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) database, we obtained relevant data for analyzing MMRN1. Using Gene Expression Profiling Interactive Analysis (GEPIA), Human Protein Atlas (HPA), TCGA, GeneMANIA, and cBioPortal, we explored the potential role of MMRN1 in different types of tumors. Tumor Immune System Interactions and Drug Bank (TISIDB) and Sangerbox were used to analyze the correlation between MMRN1 and tumor immunity. Gene set cancer analysis (GSCA) and UALCAN were used to analyze the methylation of MMRN1. GSCA was also used to analyze the drug sensitivity of MMRN1.

Results: MMRN1 is down-regulated in most cancer types and is closely related to the prognosis of cancer patients. Interestingly, in most tumors, MMRN1 is positively correlated with immune -related genes. In addition, we observed different levels of methylation and mutations in different types of tumors. Drug sensitivity analysis found that MMRN1 was negatively correlated with several drugs, including GW-2580 and TL-1-85, suggesting that it can be used to develop potential anticancer therapies.

Conclusion: Our analysis demonstrated a significant relationship between MMRN1 and prognosis, tumor immunity, and drug sensitivity of several tumors. As a rising star in cancer, it needs further research.

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MMRN1 的预后价值和免疫学作用：癌症中的一颗新星。

背景：多聚蛋白1（MMRN1）是一种因子V结合蛋白，可支持血小板粘附和血栓形成。近年来，MMRN1在癌症中的作用开始受到关注。但目前还缺乏这方面的系统研究。因此，我们利用生物信息学方法对肿瘤中的 MMRN1 进行了分析，以揭示 MMRN1 的可能作用：利用癌症基因组图谱（TCGA）和基因型-组织表达（GTEx）数据库，我们获得了分析 MMRN1 的相关数据。利用基因表达谱交互分析（GEPIA）、人类蛋白质图谱（HPA）、TCGA、GeneMANIA和cBioPortal，我们探索了MMRN1在不同类型肿瘤中的潜在作用。肿瘤免疫系统相互作用与药物库（TISIDB）和Sangerbox用于分析MMRN1与肿瘤免疫之间的相关性。基因组癌症分析（GSCA）和 UALCAN 用于分析 MMRN1 的甲基化情况。GSCA还用于分析MMRN1的药物敏感性：结果：MMRN1在大多数癌症类型中下调，并与癌症患者的预后密切相关。有趣的是，在大多数肿瘤中，MMRN1与免疫相关基因呈正相关。此外，我们还在不同类型的肿瘤中观察到不同程度的甲基化和突变。药物敏感性分析发现，MMRN1与包括GW-2580和TL-1-85在内的几种药物呈负相关，这表明它可用于开发潜在的抗癌疗法：我们的分析表明，MMRN1与多种肿瘤的预后、肿瘤免疫力和药物敏感性之间存在重要关系。作为癌症领域的后起之秀，它还需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nucleosides, Nucleotides & Nucleic Acids 生物-生化与分子生物学

CiteScore

2.60

自引率

7.70%

发文量

审稿时长

6 months

期刊介绍： Nucleosides, Nucleotides & Nucleic Acids publishes research articles, short notices, and concise, critical reviews of related topics that focus on the chemistry and biology of nucleosides, nucleotides, and nucleic acids. Complete with experimental details, this all-inclusive journal emphasizes the synthesis, biological activities, new and improved synthetic methods, and significant observations related to new compounds.

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